DuP 697
Chemical Name: 5-Bromo-2-(4-fluorophenyl)-3-[4-(methylsulfonyl)phenyl]-thiophene
Purity: ≥99%
Biological Activity
DuP 697 is a potent and selective inhibitor of cyclooxygenase-2 (IC50 values are 10 and 800 nM for COX-2 and COX-1 respectively). Inhibits prostaglandin synthesis and is anti-inflammatory in vivo. Orally active.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase.
Gierse et al.
Biochem.J., 1995;305:479 -
Anti-inflammatory and safety profile of DuP 697, a novel orally effective prostaglandin synthesis inhibitor.
Gans et al.
J.Pharmacol.Exp.Ther., 1990;254:180 -
Inhibition of cyclo-oxygenase-2 exacerbates ischaemia-induced acute myocardial dysfunction in the rabbit.
Rossoni et al.
Br.J.Pharmacol., 2002;135:1540
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Citations for DuP 697
The citations listed below are publications that use Tocris products. Selected citations for DuP 697 include:
5 Citations: Showing 1 - 5
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Resistance of cyclooxygenase-2 expressing pancreatic ductal adenocarcinoma cells against γδ T cell cytotoxicity.
Authors: Gonnermann Et al.
Oncoimmunology 2015;4:e988460
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Investigation of the functional expression of purine and pyrimidine receptors in porcine isolated pancreatic arteries.
Authors: Alsaqati Et al.
Purinergic Signal 2013;10:241
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Cholinergic Autoantibodies from Primary Sjögren's Syndrome Inhibit Mucin Production via Phospholipase C and Cyclooxygenase-2 In the Rat Submandibular Gland.
Authors: Passafaro Et al.
Neuroscience 2011;8:138
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Roles of opioid receptor subtype in the spinal antinociception of selective cyclooxygenase 2 inhibitor.
Authors: Choi Et al.
Korean J Pain 2010;23:236
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Cyclooxygenase-2-derived prostaglandin F2alpha mediates endothelium-dependent contractions in the aortae of hamsters with increased impact during aging.
Authors: Wong Et al.
Circ Res 2009;104:228
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