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DY131

Catalog #: 2266
11 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
2266/10
2266/50
DY131 | CAS No. 95167-41-2 | Estrogen and Related Receptor Agonists
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Description: Agonist selective for estrogen-related receptors ERRβ and ERRγ

Chemical Name: N-(4-(Diethylaminobenzylidenyl)-N'-(4-hydroxybenzoyl)-hydrazine

Purity: ≥99%

Product Details
Citations (11)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

DY131 is a selective agonist at estrogen-related receptors ERRβ (EC50 range = 130 - 698 nM in vitro) and ERRγ. Displays minimal activity at ERRα, ERα and ERβ at concentrations up to 30 μM. In a mouse model of hepatotoxicity, DY131 protects against LPS induced liver injury. Suppresses growth and proliferation of prostate, esophagus, gastric and breast cancer cells; concentration-dependently increases cell proliferation in T98G and U87MG cells (EC50 values are 54 nM and 62 nM respectively).

Technical Data

M.Wt:
311.38
Formula:
C18H21N3O2
Solubility:
Soluble to 10 mM in ethanol and to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
95167-41-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Estrogen-related receptor gamma serves a role in blood pressure homeostasis during pregnancy.
    Luo Y, Kumar P, Chen C, Latham J, Wang L, Tudela C, Alexander J, Shelton J, McKown L, Mendelson C
    Mol Endocrinol, 2015;28(6):965-75.
  2. Identification of an agonist ligand for estrogen-related receptors ERRβ/γ.
    Yu and Forman
    Bioorg.Med.Chem.Lett., 2005;15:1311

Product Datasheets

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Citations for DY131

The citations listed below are publications that use Tocris products. Selected citations for DY131 include:

11 Citations: Showing 1 - 10

  1. Novel metabolic system for lactic acid via LRPGC1/ERRγ signaling pathway
    Authors: Tanida Et al.
    FASEB J.  2020;34:13239
  2. Estrogen-related receptor gamma functions as a tumor suppressor in gastric cancer.
    Authors: Kang Et al.
    Nat Commun  2018;9:1920
  3. DA D1 Receptors Contribute Critically to the Apomorphine-Induced Inhibition of Form-Deprivation Myopia in Mice.
    Authors: Huang
    Invest Ophthalmol Vis Sci  2018;59(6):2623
  4. Antimitotic activity of DY131 and the estrogen-related receptor beta 2 (ERRβ2) splice variant in breast cancer.
    Authors: Heckler Et al.
    Oncotarget  2016;7:47201
  5. Trophoblast syncytialisation necessitates mitochondrial function through estrogen-related receptor-γ activation.
    Authors: Poidatz Et al.
    Mol.Hum.Reprod.  2015;21:206
  6. Messenger RNA profile analysis deciphers new Esrrb responsive genes in prostate cancer cells.
    Authors: Lu Et al.
    Neuropharmacology  2015;16:21
  7. Estrogen-related receptor γ serves a role in blood pressure homeostasis during pregnancy.
    Authors: Luo Et al.
    Mol Endocrinol  2014;28:965
  8. ERRβ splice variants differentially regulate cell cycle progression.
    Authors: Heckler and Riggins
    Cell Cycle  2014;14:31
  9. Estrogen-related receptor β deletion modulates whole-body energy balance via estrogen-related receptor γ and attenuates neuropeptide Y gene expression.
    Authors: Byerly Et al.
    Eur J Neurosci  2013;37:1033
  10. Estrogen-related receptor β deficiency alters body composition and response to restraint stress.
    Authors: Byerly Et al.
    BMC Physiol  2013;13:10

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