Ec2la
Chemical Name: N-[5-Bromo-1-[(4-fluorophenyl)methyl]-1,2-dihydro-4-methyl-2-oxo-3-pyridinyl]cycloheptanecarboxamide
Purity: ≥98%
Biological Activity
Ec2la is a CB2 receptor positive allosteric modulator. Enhances CP 55940 (Cat. No. 0949) and 2-Arachidonylglycerol (Cat. No. 1298)-stimulated binding of [35S]GTPγS to CB2 receptors, but has no effect in the absence of agonist. Exhibits antinociceptive effects in an animal model of neuropathic pain.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Identification of the first synthetic allosteric modulator of the CB2 receptors and evidence of its efficacy for neuropathic pain relief.
Gado et al.
J.Med.Chem., 2019;62:276
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