Favipiravir
Chemical Name: 6-Fluoro-3,4-dihydro-3-oxo-2-pyrazinecarboxamide
Purity: ≥98%
Biological Activity
Favipiravir is a viral RNA polymerase inhibitor; exhibits no effects on mammalian RNA polymerase. Prodrug that is phosphoribosylated by cellular enzymes to its active form, Favipiravir-ribofuranosyl-5'-triphosphate (RTP). Reduces infection rate of SARS-CoV-2 in Vero E6 cells in vitro (IC50 = 61.88 μM). Inhibits influenza virus RNA-dependent RNA polymerase (RdRP) activity (IC50 = 341 nM). Induces lethal mutagenesis in MDCK cells inoculated with seasonal influenza A (H1N1) viruses. Protects mice against Ebola virus.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro.
Wang et al.
Cell Research, 2020;30:269 -
In vitro and in vivo activities of anti-influenza virus compound T-705.
Furuta et al.
Antimicrob.Agents Chemother., 2002;46:977
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