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FHT 2344

Catalog #: 7645 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7645/10
FHT 2344 | CAS No. 2468058-90-2 | Bromodomain Inhibitors
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Description: Potent SMARCA2/4 inhibitor

Chemical Name: N-[(1S)-1-(Methoxymethyl)-2-[[4-[3-(1-methyl-1H-pyrazol-3-yl)phenyl]-2-thiazolyl]amino]-2-oxoethyl]-1-(methylsulfonyl)-1H-pyrrole-3-carboxamide

Purity: ≥95%

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Biological Activity

FHT 2344 is a potent allosteric and ATP-competitive inhibitor of SMARCA2/SMARCA4 ATPases (also known as BRM/BRG1) of the BAF complex (IC50 values are 13.8 and 26.1 nM at SMARCA2 and SMARCA4, respectively). FHT 2344 inhibits SMARCA2 transcriptional activity in a BRG1-mutant cell line and SMARCA4 transcription in a BRM-mutant cell line (IC50 values are 29.8 and 30.2 nM, respectively). Dose-dependently reduces tumor growth in a uveal melanoma xenograft model and suppresses SOX10 transcription.

Technical Data

M.Wt:
528.6
Formula:
C23H24N6O5S2
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
2468058-90-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from Foghorn Therapeutics

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