Home / Class I Histone Deacetylases Inhibitors / FK 228

FK 228

Catalog #: 3515
4 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3515/1
FK 228 | CAS No. 128517-07-7 | Class I Histone Deacetylases Inhibitors
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Description: Potent and selective class I histone deacetylase inhibitor; antitumor
Alternative Names: Depsipeptide,FR 901228,Romidepsin

Chemical Name: Cyclo[(2Z)-2-amino-2-butenoyl-L-valyl-(3S,4E)-3-hydroxy-7-mercapto-4-heptenoyl-D-valyl-D-cysteinyl], cyclic (3-5) disulfide

Purity: ≥98%

Product Details
Citations (4)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

FK 228 is a potent and selective inhibitor of class I histone deacetylases (HDACs) (IC50 values are 36, 47, 510 and 14,000 nM for HDAC1, HDAC2, HDAC4 and HDAC6 respectively). Exhibits cytotoxicity against various human tumor cell lines; also exhibits antitumor activity against human tumor xenografts.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of Romidepsin is reviewed on the Chemical Probes website.

Technical Data

M.Wt:
540.7
Formula:
C24H36N4O6S2
Solubility:
Soluble to 10 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
128517-07-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for FK 228

The citations listed below are publications that use Tocris products. Selected citations for FK 228 include:

4 Citations: Showing 1 - 4

  1. NF-κB-dependent repression of Sox18 transcription factor requires the epigenetic regulators histone deacetylases 1 and 2 in acute lung injury.
    Authors: Ting Et al.
    Front Physiol  2022;13:947537
  2. INF2-mediated actin filament reorganization confers intrinsic resilience to neuronal ischemic injury.
    Authors: Steven L Et al.
    Nat Commun  2022;13:6037
  3. Preclinical characterization of tyrosine kinase inhibitor-based targeted therapies for neuroendocrine thyroid cancer.
    Authors: Pozo Et al.
    Oncotarget  2018;9:37662
  4. Class I histone deacetylase inhibitors inhibit the retention of BRCA1 and 53BP1 at the site of DNA damage.
    Authors: Fukuda Et al.
    J Pharmacol Exp Ther  2015;106:1050

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