Fumonisin B1

Tocris Bioscience | Catalog # 3103

Inhibitor of sphingosine N-acyltransferase
Tocris Bioscience
Discontinued Product
3103 has been discontinued. View all Other Transferase Inhibitors products.

Key Product Details

Description

Inhibitor of sphingosine N-acyltransferase
View all Other Transferase Inhibitors »

Product Description

Fumonisin B1 is a mycotoxin produced by Fusarium moniliforme. Potently inhibits sphingosine N-acyltransferase (ceramide synthase), causing an accumulation of sphingoid bases (IC50 ~ 75 nM). Also inhibits protein phosphatases; IC50 values are 80, 300, 400, 500 and 3000 μM for PP5, PP2Cα, PP2A, PP1γ2 and PP2B respectively.

Product Specifications for Fumonisin B1

Molecular Weight

721.83

Formula

C34H59NO15

Storage

Store at +4°C

Chemical Name

1,1'-[(1S,2R)-1-[(2S,4R,9R,11S,12S)-12-Amino-4,9,11-trihydroxy-2-methyltridecyl]-2-[(1R)-1-methylpentyl]-1,2-ethanediyl-1,2,3-(2R,2'R)-propanetricarboxylic acid ester.

CAS Number

116355-83-0

PubChem ID

2733487

InChI Key

UVBUBMSSQKOIBE-DSLOAKGESA-N

SMILES

C[C@H](N)[C@@H](O)C[C@H](O)CCCC[C@@H](O)C[C@H](C)C[C@H](OC(C[C@H]([C@@](O)=O)CC(O)=O)=O)[C@H](OC(C[C@H]([C@@](O)=O)CC(O)=O)=O)[C@H](C)CCCC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 7.22 10

Preparing Stock Solutions for Fumonisin B1

The following data is based on the product molecular weight 721.83.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 13.85 mL 69.27 mL 138.54 mL
0.5 mM 2.77 mL 13.85 mL 27.71 mL
1 mM 1.39 mL 6.93 mL 13.85 mL
5 mM 0.28 mL 1.39 mL 2.77 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for Fumonisin B1

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Fumonisin B1

For research use only

⚠ WARNING: This product can expose you to chemicals including Fumonisin B1, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov

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