GYY 4137 morpholine salt

Key Product Details

Product Description

GYY 4137 morpholine salt is a slow-releasing H₂S donor. Exhibits vasodilator and antihypertensive activity. Activity causes slow dilation of blood vessels in vitro and in vivo; does not influence vascular smooth muscle cell viability in culture. Water-soluble.

Product Specifications for GYY 4137 morpholine salt

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for GYY 4137 morpholine salt

The following data is based on the product molecular weight 376.47.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.66 mL	13.28 mL	26.56 mL
5 mM	0.53 mL	2.66 mL	5.31 mL
10 mM	0.27 mL	1.33 mL	2.66 mL
50 mM	0.05 mL	0.27 mL	0.53 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Liu Hydrogen sulfide donor, GYY4137, exhibits anti-atherosclerotic activity in high fat fed apolipoprotein E^-/- mice. Br.J.Pharmacol. [Epub ahead of print] 2013 PMID: 23713790
• Whiteman The effect of hydrogen sulfide donors on lipopolysaccaride-induced formation of inflammatory mediators in macrophages. Antioxid.Redox.Signal. 2010 PMID: 19769459
• Lee The slow-releasing hydrogen sulfide donor, GYY4137, exhibits novel anti-cancer effects in vitro and in vivo. PLoS One 2011 PMID: 21701688
• Li Characterization of a novel, water-soluble hydrogen sulfide-releasing molecule (GYY4137). Circulation 2008 PMID: 18443240

Product Documents for GYY 4137 morpholine salt