Heclin
Chemical Name: N-(4-Acetylphenyl)-3-(5-ethyl-2-furanyl)-2-propenamide
Purity: ≥98%
Biological Activity
Heclin is a HECT E3 ubiquitin ligase inhibitor; inhibits Nedd4, Smurf2 and WWP1 (IC50 values are 6.3, 6.8 and 6.9 μM respectively). Selective for HECT-mediated over RING-mediated ubiquitination.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Peptide and small molecule inhibitors of HECT-type ubiquitin ligases.
Mund et al.
Proc.Natl.Acad.Sci.U.S.A., 2014;111:16736
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Citations for Heclin
The citations listed below are publications that use Tocris products. Selected citations for Heclin include:
4 Citations: Showing 1 - 4
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Tyrphostin AG1024 Suppresses Coronaviral Replication by Downregulating JAK1 via an IR/IGF-1R Independent Proteolysis Mediated by Ndfip1/2_NEDD4-like E3 Ligase Itch.
Authors: Cheng-Wei Et al.
Pharmaceuticals (Basel) 2022;15
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Myocardial infarction affects Cx43 content of extracellular vesicles secreted by cardiomyocytes.
Authors: Saskia C Et al.
Life Sci Alliance 2020;3
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The E3 ubiquitin ligase Smurf2 regulates PARP1 stability to alleviate oxidative stress-induced injury in human umbilical vein endothelial cells.
Authors: Yingxian Et al.
J Cell Mol Med 2020;24:4600-4611
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Natural cardenolides suppress coronaviral replication by downregulating JAK1 via a Na+/K+-ATPase independent proteolysise
Authors: Yang Et al.
Biochem Pharmacol 2020;180
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