Herbimycin A
Chemical Name: (15R)-17-demethoxy-15-methoxy-11-O-methyl-geldanamycin
Purity: ≥95%
Biological Activity
Herbimycin A is an ansamycin antibiotic that acts as a Src family kinase inhibitor. Binds to the SH domain and inhibits the activity of p60v-src and p210BCR-ABL. Exhibits antiangiogenic activity in endothelial cells in vitro. Also inhibits Hsp90 and impairs recovery from heat shock.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Labeling of v-Src and BCR-ABL tyrosine kinases with [14C]herbimycin A and its use in the elucidation of the kinase inactivation mechanism.
Fukazawa et al.
FEBS Lett., 1994;340:155 -
Herbimycin A inhibits angiogenic activity in endothelial cells and reduces neovascularization in a rat model of retinopathy of prematurity.
McCollum et al.
Exp.Eye Res., 2004;78:987 -
Inhibition of Hsp90 function delays and impairs recovery from heat shock.
Duncan
FEBS J., 2005;272:5244
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