Human FXR/NR1H4 Antibody Summary
aa 2-126
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
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Preparation and Storage
Background: FXR/NR1H4
Farnesoid X-activated Receptor (FXR, HRR-1, BAR, RIP14; NR1H4) is a member of the Orphan Nuclear Receptor family. FXR is expressed in the liver, intestinal villi, renal tubes and adrenal cortex. FXR is a global regulator of bile acid metabolism. Two genes, cholesterol 7a-hydroxylase (CYP7A1) and IBABP (Ileal Bile Acid Binding Protein), which are implicated in bile acid biosynthesis and recycling, respectively, are target genes of FXR. FXR is shown to be transcriptionally activated by farnesol metabolites such as farnesol itself and juvenile hormone III. FXR binds to DNA only as a heterodimer with Retinoid X Receptor (RXR).
Product Datasheets
Citations for Human FXR/NR1H4 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
14
Citations: Showing 1 - 10
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PTX promotes breast cancer migration and invasion by recruiting ATF4 to upregulate FGF19
Authors: Xue, T;Wang, X;Pan, X;Liu, M;Xu, F;
Cellular signalling
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
Regulation of Chromatin Accessibility by the Farnesoid X Receptor Is Essential for Circadian and Bile Acid Homeostasis In Vivo
Authors: Haider M. Hassan, Oladapo Onabote, Majdina Isovic, Daniel T. Passos, Frederick A. Dick, Joseph Torchia
Cancers (Basel)
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Pentacyclic triterpenes modulate farnesoid X receptor expression in colonic epithelial cells: implications for colonic secretory function
Authors: CM Fallon, JS Smyth, A Quach, N Lajczak-Mc, A O'Toole, KE Barrett, H Sheridan, SJ Keely
The Journal of Biological Chemistry, 2022-10-06;0(0):102569.
Species: Human
Sample Types: Cell Culture Supernates
Applications: Western Blot -
Farnesoid X Receptor Deficiency Induces Hepatic Lipid and Glucose Metabolism Disorder via Regulation of Pyruvate Dehydrogenase Kinase 4
Authors: W Deng, W Fan, T Tang, H Wan, S Zhao, Y Tan, KA Oware, J Tan, J Li, S Qu
Oxidative Medicine and Cellular Longevity, 2022-02-24;2022(0):3589525.
Species: Mouse
Sample Types: Tissue Lysates
Applications: Western Blot -
Pathophysiology of reflux oesophagitis: role of Toll-like receptors 2 and 4 and Farnesoid X receptor
Authors: Nortunen M, VAkiparta N, Porvari K et al.
Virchows Archiv : an international journal of pathology
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Nuclear receptor FXR impairs SK‑Hep‑1 cell migration and invasion by inhibiting the Wnt/β‑catenin signaling pathway
Authors: Qianqian Li, Ningbo Li, Yeting Zeng, Xinrui Wang, Jie Li, Hongying Su et al.
Oncology Letters
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Farnesoid X receptor as marker of osteotropism of breast cancers through its role in the osteomimetism of tumor cells
Authors: L Absil, F Journé, D Larsimont, JJ Body, L Tafforeau, D Nonclercq
BMC Cancer, 2020-07-10;20(1):640.
Species: Human
Sample Types: Whole Tissue
Applications: IHC -
Loss of Thymine DNA Glycosylase Causes Dysregulation of Bile Acid Homeostasis and Hepatocellular Carcinoma
Authors: HM Hassan, M Isovic, B Kolendowsk, N Bauer-Mais, O Onabote, M Cecchini, A Haig, S Maleki Var, TM Underhill, J Torchia
Cell Rep, 2020-04-07;31(1):107475.
Species: Mouse
Sample Types: Tissue Homogenates
Applications: Immunoprecipitation -
THE FARNESOID X RECEPTOR INHIBITS THE TRANSCRIPTIONAL ACTIVITY OF THE CARBOHYDRATE RESPONSE ELEMENT BINDING PROTEIN IN HUMAN HEPATOCYTES -- R2
Authors: Caron S, Samanez CH, Dehondt H et al.
Mol Cell Biol
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Immunomodulatory glycan LNFPIII alleviates hepatosteatosis and insulin resistance through direct and indirect control of metabolic pathways.
Nat Med, 2012-10-28;18(11):1665-72.
Species: Mouse
Sample Types: Cell Lysates
Applications: Western Blot -
FXR Controls the Tumor Suppressor NDRG2 and FXR Agonists Reduce Liver Tumor Growth and Metastasis in an Orthotopic Mouse Xenograft Model.
Authors: Deuschle U, Schuler J, Schulz A, Schluter T, Kinzel O, Abel U, Kremoser C
PLoS ONE, 2012-10-09;7(10):e43044.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
Bile acids down-regulate caveolin-1 in esophageal epithelial cells through sterol responsive element-binding protein.
Authors: Prade E, Tobiasch M, Hitkova I, Schaffer I, Lian F, Xing X, Tanzer M, Rauser S, Walch A, Feith M, Post S, Rocken C, Schmid RM, Ebert MP, Burgermeister E
Mol. Endocrinol., 2012-04-03;26(5):819-32.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
Farnesoid X receptor protects human and murine gastric epithelial cells against inflammation-induced damage.
Authors: Lian F, Xing X, Yuan G, Schafer C, Rauser S, Walch A, Rocken C, Ebeling M, Wright MB, Schmid RM, Ebert MP, Burgermeister E
Biochem. J., 2011-09-01;438(2):315-23.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
Farnesoid X receptor, overexpressed in pancreatic cancer with lymph node metastasis promotes cell migration and invasion.
Authors: Lee JY, Lee KT, Lee JK, Lee KH, Jang KT, Heo JS, Choi SH, Kim Y, Rhee JC
Br. J. Cancer, 2011-03-01;104(6):1027-37.
Species: Human
Sample Types: Whole Cells, Whole Tissue
Applications: IHC-P, Western Blot
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