Human IFN-epsilon Antibody Summary
Leu22-Arg208
Accession # Q86WN2
Applications
This antibody functions as an ELISA detection antibody when paired with Mouse Anti-Human IFN-epsilon Monoclonal Antibody (Catalog # MAB91471).
This product is intended for assay development on various assay platforms requiring antibody pairs.
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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IFN-epsilon in Human Endometrial Cancer Tissue. IFN-epsilon was detected in immersion fixed paraffin-embedded sections of human endometrial cancer tissue using Mouse Anti-Human IFN-epsilon Monoclonal Antibody (Catalog # MAB9147) at 1 µg/mL for 1 hour at room temperature followed by incubation with the Anti-Mouse IgG VisUCyte™ HRP Polymer Antibody (Catalog # VC001). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to cancer cell cytoplasm. View our protocol for IHC Staining with VisUCyte HRP Polymer Detection Reagents.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: IFN-epsilon
Interferon-epsilon (IFNe) is a type I interferon with expression limited to the brain, lung, intestine and reproductive tract. It has been proposed that unlike other type I interferons, IFNe plays a role in mucosal immunity and protects against pathogens including chlamidia, HIV and herpes simplex virus 2. Its expression is upregulated by TNF alpha. Unlike other type-1 interferons, IFNe is also hormonally regulated, and mouse and human IFNe have been shown to have a binding site in their promoters for progesterone receptor. Epithelial cells isolated from uterine endometrium have higher IFNee expression in the proliferative phase, when estrogen levels are highest. IFNe is the only IFN isoform constituitively expressed in HeLa cells.
Product Datasheets
Citation for Human IFN-epsilon Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
1 Citation: Showing 1 - 1
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Defining a role for Interferon Epsilon in normal and complicated pregnancies
Authors: D Miller, R Romero, M Kacerovsky, I Musilova, J Galaz, V Garcia-Flo, Y Xu, E Pusod, C Demery-Pou, P Gutierrez-, TN Liu, E Jung, KR Theis, LA Coleman, N Gomez-Lope
Heliyon, 2022-07-16;8(7):e09952.
Species: Human
Sample Types: Whole Tissue
Applications: IHC
FAQs
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