Human PDGF-D Antibody Summary
Asp253-Arg370
Accession # Q9GZP0
*Small pack size (-SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
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Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of Mouse PDGF-D/SCDGFB by Western Blot RPE-specific overexpression of PDGF-D in vivo.(A) Schematic diagram illustrating the AAV vector carrying GFP (AAV-GFP) or human PDGF-D (AAV-PDGF-D) gene and RPE specific VDM2 promoter. (B) Real-time PCR results of relative mRNA expression of PDGF-D in retinae or RPE-choroid complex from mice injected with AAV-GFP or AAV-PDGF- D for 4 weeks. (C) Representative immunoblotting showing PDGF-D expression in mouse retinae or RPE-choroid complex. (D) Quantifications of PDGF-D protein levels in (C). (E) Immunofluorescence images highlighting RPE-specific expression of GFP or PDGF-D in mouse RPE-choroid complex with 4 weeks AAV-GFP or AAV-PDGF-D injection, respectively. Scale bar: 50 μm. n = 5, ****p < 0.0001, ns: not significant. Image collected and cropped by CiteAb from the following open publication (https://pubmed.ncbi.nlm.nih.gov/34150781), licensed under a CC-BY license. Not internally tested by R&D Systems.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: PDGF-D
PDGF-D, also named spinal cord-derived growth factor B (SCDGF-B) is a member of the PDGF/VEGF family.
Product Datasheets
Citations for Human PDGF-D Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 7
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Overexpression of Platelet-derived Growth Factor-D as a Poor Prognosticator in Endometrial Cancer
Authors: Jie Ding, Xiao-Mao Li, Sui-Ling Liu, Yu Zhang, Tian Li
Asian Pacific Journal of Cancer Prevention
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Stromal reprogramming through dual PDGFRalpha/beta blockade boosts the efficacy of anti-PD-1 immunotherapy in fibrotic tumors
Authors: T Akiyama, T Yasuda, T Uchihara, N Yasuda-Yos, BJY Tan, A Yonemura, T Semba, J Yamasaki, Y Komohara, K Ohnishi, F Wei, L Fu, J Zhang, F Kitamura, K Yamashita, K Eto, S Iwagami, H Tsukamoto, T Umemoto, M Masuda, O Nagano, Y Satou, H Saya, P Tan, H Baba, T Ishimoto
Cancer Research, 2023-03-02;0(0):.
Species: Human
Sample Types: Whole Tissue
Applications: Immunohistochemistry -
High expression of PDGFR-? in prostate cancer stroma is independently associated with clinical and biochemical prostate cancer recurrence
Authors: Y Nordby, E Richardsen, M Rakaee, N Ness, T Donnem, HR Patel, LT Busund, RM Bremnes, S Andersen
Sci Rep, 2017-02-24;7(0):43378.
Species: Human
Sample Types: Whole Tissue
Applications: IHC -
Dynamic regulation of platelet-derived growth factor D (PDGF-D) activity and extracellular spatial distribution by matriptase-mediated proteolysis.
Authors: Huang W, Kim H
J Biol Chem, 2015-02-12;290(14):9162-70.
Species: Human
Sample Types: Cell Lysates
Applications: Immunoprecipitation -
Effects of PDGF-C and PDGF-D on monocyte migration and MMP-2 and MMP-9 expression.
Authors: Wagsater D, Zhu C, Bjorck HM, Eriksson P
Atherosclerosis, 2008-05-22;202(2):415-23.
Species: Human
Sample Types: Cell Lysates, Whole Cells, Whole Tissue
Applications: IHC-Fr, Neutralization, Western Blot -
Expression of platelet-derived growth factors C and D in the synovial membrane of patients with rheumatoid arthritis and osteoarthritis.
Authors: Pohlers D, Huber R, Ukena B, Kinne RW
Arthritis Rheum., 2006-03-01;54(3):788-94.
Species: Human
Sample Types: Tissue Homogenates, Whole Tissue
Applications: IHC, Western Blot -
Platelet-Derived Growth Factors in Non-GIST Soft-Tissue Sarcomas Identify a Subgroup of Patients with Wide Resection Margins and Poor Disease-Specific Survival
Authors: Thomas Karsten Kilvaer, Andrej Valkov, Sveinung W. Sorbye, Tom Donnem, Eivind Smeland, Roy Martin Bremnes et al.
Sarcoma
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