Human PLUNC Antibody

Catalog # Availability Size / Price Qty
AF1897
AF1897-SP
Product Details
Citations (4)
FAQs
Supplemental Products
Reviews

Human PLUNC Antibody Summary

Species Reactivity
Human
Specificity
Detects human PLUNC in direct ELISAs and Western blots.
Source
Polyclonal Goat IgG
Purification
Antigen Affinity-purified
Immunogen
E. coli-derived recombinant human PLUNC
Gln20-Val256
Accession # Q9NP55
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Western Blot
0.1 µg/mL
Recombinant Human PLUNC
ELISA

This antibody functions as an ELISA detection antibody when paired with Mouse Anti-Human PLUNC Monoclonal Antibody (Catalog # MAB18971).

This product is intended for assay development on various assay platforms requiring antibody pairs.

 

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Reconstitution
Reconstitute at 0.2 mg/mL in sterile PBS.
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Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: PLUNC

PLUNC, also named SPLUNC1, is a secreted protein that is expressed in the secretory ducts and submucosal glands of tracheobronchial tissues. It is structurally related to bactericidal/permeability-increasing protein (BPI) and lipopolysaccaride binding protein (LBP), which are central to the host defense against gram-negative bacteria. PLUNC belongs to the short subfamily of PLUNC family proteins and have homology only to the N-terminal domains of BPI. PLUNC may function in the innate immune response against bacteria.

Long Name
Palate, Lung, and Nasal Epithelium Associated
Entrez Gene IDs
51297 (Human)
Alternate Names
bA49G10.5; BPIFA1; ligand-binding protein RYA3; LPLUNC3; Lung-specific protein X; LUNX; LUNXNASG; Nasopharyngeal carcinoma-related protein; Palate lung and nasal epithelium clone protein; palate, lung and nasal epithelium associated; palate, lung and nasal epithelium carcinoma associated; PLUNC; protein Plunc; Secretory protein in upper respiratory tracts; SPLUNC1; SPLUNC1SPURT; tracheal epithelium enriched protein; Tracheal epithelium-enriched protein; Von Ebner protein Hl

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Citations for Human PLUNC Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

4 Citations: Showing 1 - 4
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  1. SPLUNC1 is a negative regulator of the Orai1 Ca2+ channel
    Authors: T Wu, AS Goriounova, EN Worthingto, JA Wrennall, A Ghosh, S Ahmad, M Flori Sass, R Tarran
    Physiological Reports, 2022-05-01;10(10):e15306.
    Species: Human
    Sample Types: Whole Cells
    Applications: Immunoprecipitation
  2. A Rare Mutation in SPLUNC1 Affects Bacterial Adherence and Invasion in Meningococcal Disease
    Authors: Bayarchimeg Mashbat, Evangelos Bellos, Stephanie Hodeib, Fadil Bidmos, Ryan S Thwaites, Yaxuan Lu et al.
    Clinical Infectious Diseases
  3. Airway symptoms and biological markers in nasal lavage fluid in subjects exposed to metalworking fluids.
    Authors: Fornander L, Graff P, Wahlen K, Ydreborg K, Flodin U, Leanderson P, Lindahl M, Ghafouri B
    PLoS ONE, 2013-12-31;8(12):e83089.
    Species: Human
    Sample Types: Nasal Lavage Fluid
    Applications: Western Blot
  4. Quantitation of SPLUNC1 in saliva with an xMAP particle-based antibody capture and detection immunoassay
    Authors: Karl G. Kohlgraf, Abbey R. Ackermann, Kindra K. Burnell, Rupasree N. Srikantha, Sophie A. Joly, Jennifer A. Bartlett et al.
    Archives of Oral Biology

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