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IHR 1

Catalog #: 5554 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5554/10
5554/50
IHR 1 | CAS No. 548779-60-8 | Smoothened Receptor Antagonists
1 Image
Description: Potent Smo antagonist

Chemical Name: N,N'-1,4-Phenylenebis[2,5-dichlorobenzamide]

Purity: ≥99%

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Biological Activity

IHR 1 is a potent Smo antagonist (IC50 = 7.6 nM). Selectively inhibits Hedgehog signaling over Wnt and Notch signaling pathways. Blocks Smo accumulation in primary cilium in vitro.

Fluorescent Analog also available.

Technical Data

M.Wt:
454.13
Formula:
C20H12Cl4N2O2
Solubility:
Soluble to 20 mM in DMSO with gentle warming
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
548779-60-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

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