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JH 295

Catalog #: 4322 Datasheet / COA / SDS
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4322/2
JH 295 | CAS No. 1311143-71-1 | Nek2 Kinase Inhibitors
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Description: Irreversible Nek2 inhibitor

Chemical Name: N-[(3Z)-3-[(2-Ethyl-4-methyl-1H-imidazol-5-yl)methylene]-2,3-dihydro-2-oxo-1H-indol-5-yl]-2-propynamide

Purity: ≥98%

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Biological Activity

JH 295 is an irreversible Nek2 inhibitor (IC50=770 nM). Inhibits Nek2 via alkylation of residue Cys22. Displays 5-fold selectivity for Nek2 over Cdk1. Exhibits no significant effect on Aurora B or Plk1 kinases, bipolar spindle assembly or spindle assembly checkpoint. Cell permeable.

Technical Data

M.Wt:
320.35
Formula:
C18H16N4O2
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1311143-71-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Irreversible Nek2 kinase inhibitors with cellular activity.
    Henise et al.
    J.Med.Chem., 2011;54:4133

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