JWH 133

Tocris Bioscience | Catalog # 1343

Potent and selective CB2 agonist
Tocris Bioscience

Key Product Details

Description

Potent and selective CB2 agonist
View all Cannabinoid R2/CB2 Agonists »

Product Description

JWH 133 is a potent CB2 selective agonist (Ki = 3.4 nM). Approx. 200-fold selective over CB1 receptors. Active in vivo, reducing spasticity in a murine model of multiple sclerosis. Activity also enhances the release of IL-10 by LPS/IFN-γ-stimulated macrophages and results in downregulation of the IL-12 subunit p40.

Product Specifications for JWH 133

Molecular Weight

312.49

Formula

C22H32O

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

(6aR,10aR)-3-(1,1-Dimethylbutyl)-6a,7,10,10a-tetrahydro-6,6,9-trimethyl-6H-dibenzo[b,d]pyran

CAS Number

259869-55-1

PubChem ID

6918505

InChI Key

YSBFLLZNALVODA-RBUKOAKNSA-N

SMILES

[H][C@]([C@]3([H])C(C)(C)O2)(CC(C)=CC3)C1=C2C=C(C(C)(C)CCC)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 6.25 20
Ethanol 31.25 100

Preparing Stock Solutions for JWH 133

The following data is based on the product molecular weight 312.49.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.20 mL 16.00 mL 32.00 mL
5 mM 0.64 mL 3.20 mL 6.40 mL
10 mM 0.32 mL 1.60 mL 3.20 mL
50 mM 0.06 mL 0.32 mL 0.64 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 225 publications citing the usage of this product.

Product Documents for JWH 133

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for JWH 133

For research use only

Related Research Areas

Bioactive Lipids and Receptors

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  • In vitro Splenocyte Gut Homing Assays
    Name: Anonymous
    Assay Type: In Vitro
    Cell Line/Tissue: Spleen
    Verified Customer | Posted 08/22/2017
    In vitro assay on splenocytes to determine if treatment had any affect on gut homing molecules (used 10uM/mL)

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