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JX 06

Catalog #: 5845 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5845/10
5845/50
JX 06 | CAS No. 729-46-4 | PDK-1 Inhibitors
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Description: Potent and selective pyruvate dehydrogenase kinase (PDK) 1/2/3 inhibitor

Chemical Name: Bis(morpholinothiocarbonyl) disulfide

Purity: ≥98%

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Biological Activity

JX 06 is a potent and selective pyruvate dehydrogenase kinase (PDK) 1/2/3 inhibitor (IC50 values are 49, 101 and 313 nM for PDK1, PDK2 and PDK3, respectively). Exhibits selectivity for PDK1/2/3 over PDK4 and a panel of 323 other kinases. Suppresses A549 lung cancer cell proliferation in vitro. Reduces tumor volume of A549 xenografts in mice.

Technical Data

M.Wt:
324.51
Formula:
C10H16N2O2S4
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
729-46-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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