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K 579

Catalog #: 2790
2 Citations Datasheet / COA / SDS

Discontinued Product

2790 has been discontinued.
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K 579 | CAS No. 440100-64-1 | DPPIV/CD26 Inhibitors
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Description: Dipeptidyl peptidase IV (DPP-IV) inhibitor

Chemical Name: (2S)-1-[[[4-Methyl-1-(2-pyrimidinyl)-4-piperidinyl]amino]acetyl]-2-pyrrolidinecarbonitrile

Purity: ≥99%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

K 579 is a dipeptidyl peptidase IV inhibitor. Inhibits rat, canine, human and monkey enzymes with IC50 values of 3, 5, 8, and 8 nM respectively. Long-acting hypoglycemic agent; attenuates glucose excursion following glucose loading in Zucker fatty rats.

Technical Data

M.Wt:
328.41
Formula:
C17H24N6O
Solubility:
Soluble to 50 mM in 1eq. HCl and to 100 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at +4°C
CAS No:
440100-64-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for K 579

The citations listed below are publications that use Tocris products. Selected citations for K 579 include:

2 Citations: Showing 1 - 2

  1. Combined treatment with dipeptidyl peptidase 4 (DPP4) inhibitor sitagl. and elemental diets reduced indomethacin-induced intestinal injury in rats via the increase of mucosal glucagon-like peptide-2 concentration.
    Authors: Fujiwara Et al.
    Arterioscler Thromb Vasc Biol  2015;56:155
  2. Dipeptidyl peptidase IV inhibition prevents the formation and promotes the healing of indomethacin-induced intestinal ulcers in rats.
    Authors: Inoue Et al.
    Dig Dis Sci  2014;59:1286

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