KC 12291 hydrochloride

Key Product Details

Product Description

KC 12291 hydrochloride is an orally active atypical voltage-gated sodium channel blocker. Inhibits sustained sodium currents (I_NaL) and prevents diastolic contracture in isolated atria in vitro (IC₅₀ values are 9.6 and 0.55 - 0.79 μM respectively). Displays anti-ischemic, bradycardic and cardioprotective activity in vivo.

Product Specifications for KC 12291 hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for KC 12291 hydrochloride

The following data is based on the product molecular weight 449.99.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.44 mL	22.22 mL	44.45 mL
2.5 mM	0.89 mL	4.44 mL	8.89 mL
5 mM	0.44 mL	2.22 mL	4.44 mL
25 mM	0.09 mL	0.44 mL	0.89 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Decking Cardioprotective actions of KC 12291. Naunyn-Schmied.Arch.Pharmacol.
• John KC 12291: an atypical sodium channel blocker with myocardial antiischemic properties. Cardiovasc.Drug Rev. 2004 PMID: 14978516
• Letienne Pharmacological characterisation of sodium channels in sinoatrial node pacemaking in the rat heart. Eur.J.Pharmacol. 2006 PMID: 16368090
• Tamareille Anti-ischemic compound KC 12291 prevents diastolic contracture in isolated atria by blockade of voltage-gated sodium channels. J.Cardiovasc.Pharmacol. 2002 PMID: 12198320

Product Documents for KC 12291 hydrochloride