Home / Lysophosphatidic Acid (LPA) Receptor Antagonists / Ki 16425

Ki 16425

Catalog #: 5056
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5056/25
5056/5
Ki 16425 | CAS No. 355025-24-0 | Lysophosphatidic Acid (LPA) Receptor Antagonists
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Description: LPA1 and LPA3 receptor antagonist

Chemical Name: 3-[[[4-[4-[[[1-(2-Chlorophenyl)ethoxy]carbonyl]amino]-3-methyl-5-isoxazolyl]phenyl]methyl]thio]propanoic acid

Purity: ≥98%

Product Details
Citations (2)
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Biological Activity

Ki 16425 is an antagonist of the lysophosphatidic acid receptors LPA1 and LPA3 (Ki values are 0.25 and 0.36 μM respectively, in a GTPγS binding assay). Blocks LPA-induced dephosphorylation of Yes-associated protein (YAP) and WW domain-containing transcription regulator protein 1 (TAZ), inhibiting the Hippo signaling pathway, in HEK293A cells.

Technical Data

M.Wt:
474.96
Formula:
C23H23ClN2O5S
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in 1eq. NaOH
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
355025-24-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Ki 16425

The citations listed below are publications that use Tocris products. Selected citations for Ki 16425 include:

2 Citations: Showing 1 - 2

  1. Ovarian cancer cell-derived lysophosphatidic acid induces glycolytic shift and cancer-associated fibroblast-phenotype in normal and peritumoral fibroblasts.
    Authors: Jinsong Et al.
    Cancer Lett  2019;442:464-474
  2. Lysophosphatidic acid mediates myeloid differentiation within the human bone marrow microenvironment.
    Authors: Evseenko Et al.
    PLoS One  2013;8:e63718

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