Home / Active Degraders / KL 465

KL 465

Catalog #: 8854 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
8854/5
KL 465 | CAS No. 3057446-82-6 | Active Degraders
1 Image
Description: MAGE-A3 Degrader (PROTAC®)

Chemical Name: (2S,4R)-N-(2-(2-(2-(2-((4-(Furan-2-carbonyl)piperazin-1-yl)methyl)-4-(1H-indazol-4-yl)phenoxy)ethoxy)ethoxy)-4-(4-methylthiazol-5-yl)benzyl)-4-hydroxy-1-((S)-3-methyl-2-(1-oxoisoindolin-2-yl)butanoyl)pyrrolidine-2-carboxamide

Purity: ≥98%

Product Details
Reviews
Biological Activity Technical Data Product Datasheets Calculators

Biological Activity

KL 465 is a MAGE-A3 Degrader (PROTAC®) (DC50 = 2 μM; Dmax = 60%). MAGE-A3 degradation with KL 465 decreases cancer cell viability and is VHL dependent.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Technical Data

M.Wt:
1021.2
Formula:
C56H60N8O9S
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
3057446-82-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

Reconstitution Calculator
Molarity Calculator

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for KL 465

There are currently no reviews for this product. Be the first to review KL 465 and earn rewards!

Have you used KL 465?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.