KU 0063794

Key Product Details

Product Description

KU 0063794 is a selective inhibitor of mammalian target of rapamycin (mTOR) (IC₅₀ ~10 nM for mTORC1 and mTORC2). Displays no activity at PI 3-kinase or 76 other kinases tested. Inhibits activation and hydrophobic motif phosphorylation of Akt, S6K and SGK, but not RSK. Suppresses cell growth and induces G₁ cell cycle arrest in vitro.

Product Specifications for KU 0063794

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for KU 0063794

The following data is based on the product molecular weight 465.54.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.48 mL	107.40 mL	214.80 mL
0.5 mM	4.30 mL	21.48 mL	42.96 mL
1 mM	2.15 mL	10.74 mL	21.48 mL
5 mM	0.43 mL	2.15 mL	4.30 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 56 publications citing the usage of this product.

• Garcia-Martinez Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR). Biochem.J. 2009 PMID: 19402821

Product Documents for KU 0063794