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L-364,373

Catalog #: 2660
4 Citations Datasheet / COA / SDS

Discontinued Product

2660 has been discontinued.
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L-364,373 | CAS No. 103342-82-1 | Voltage-gated Potassium Channel Activators
1 Image
Description: KV7.1 channel activator, activates IKs
Alternative Names: R-L3

Chemical Name: 5-(2-Fluorophenyl)-1,3-dihydro-3-(1H-indol-3-ylmethyl)-1-methyl-2H-1,4-benzodiazepin-2-one

Purity: ≥98%

Product Details
Citations (4)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

L-364,373 is an activator of KV7.1 (KCNQ1) channels. Activates the cardiac IKs current that decreases action potential duration (APD) in cardiac myocytes.

Technical Data

M.Wt:
397.44
Formula:
C25H20FN3O
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
103342-82-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Pharmacological dissection of K(V)7.1 channels in systemic and pulmonary arteries.
    Chadha et al.
    Br.J.Pharmacol., 2012;166:1377
  2. Pharmacological activation of normal and arrhythmia-associated mutant KCNQ1 potassium channels.
    Seebohm et al.
    Circ.Res., 2003;93:941
  3. Rb+ efflux through functional activation of cardiac KCNQ1/minK channels by the benzodiazepine R-L3 (L-364,373).
    Jow et al.
    Assay Drug Dev.Technol., 2006;4:443
  4. A novel benzodiazepine that activates cardiac slow delayed rectifier K+ currents.
    Salata et al.
    Am.Soc.Pharmacol.Exp.Ther., 1998;53:220

Product Datasheets

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Citations for L-364,373

The citations listed below are publications that use Tocris products. Selected citations for L-364,373 include:

4 Citations: Showing 1 - 4

  1. Cardiac glycosides decrease influenza virus replication by inhibiting cell protein translational machinery.
    Authors: Amarelle Et al.
    Am J Physiol Lung Cell Mol Physiol  2019;316:L1094
  2. Lean and Obese Coronary Perivascular Adipose Tissue Impairs Vasodilation via Differential Inhibition of Vascular Smooth Muscle K+ Channels.
    Authors: Noblet Et al.
    Arterioscler Thromb Vasc Biol  2015;35:1393
  3. Contribution of kv7.4/kv7.5 heteromers to intrinsic and calcitonin gene-related peptide-induced cerebral reactivity.
    Authors: Chadha Et al.
    Arterioscler Thromb Vasc Biol  2014;34:887
  4. Pharmacological dissection of K(v)7.1 channels in systemic and pulmonary arteries.
    Authors: Chadha Et al.
    Br J Pharmacol  2012;166:1377

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