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LIMKi 3

Catalog #: 4745
5 Citations Datasheet / COA / SDS
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4745/10
LIMKi 3 | CAS No. 1338247-35-0 | LIMK Inhibitors
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Description: Potent LIM kinase inhibitor; antitumor
Alternative Names: BMS 5

Chemical Name: N-[5-[1-(2,6-Dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]-2-thiazolyl]-2-methylpropanamide

Purity: ≥98%

Product Details
Citations (5)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

LIMKi 3 is a potent LIM kinase inhibitor (IC50 values are 7 and 8 nM for LIMK1 and LIMK2 respectively). Inhibits cofilin phosphorylation in MDA-MB-231 breast cancer cells. Reduces MDA-MB-231 tumor cell invasion in a 3D matrigel invasion assay.

Technical Data

M.Wt:
431.29
Formula:
C17H14Cl2F2N4OS
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1338247-35-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. The actin-severing protein cofilin is downstream of neuregulin signaling and is essential for schwann cell myelination.
    Sparrow N, Manetti ME, Bott M, Fabianac T, Petrilli A, Bates ML, Bunge MB, Lambert S, Fernandez-Valle C.
    J Neurosci;32(15):5284-97.
  2. Identification of a nonkinase target mediating cytotoxicity of novel kinase inhibitors.
    Ross-Macdonald et al.
    Mol.Cancer Ther., 2008;7:3490
  3. LIM kinases are required for invasive path generation by tumor and tumor-associated stromal cells.
    Scott et al.
    J.Cell Biol., 2010;191:169

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Citations for LIMKi 3

The citations listed below are publications that use Tocris products. Selected citations for LIMKi 3 include:

5 Citations: Showing 1 - 5

  1. The Wdr1-LIMK-Cofilin Axis Controls B Cell Antigen Receptor-Induced Actin Remodeling and Signaling at the Immune Synapse.
    Authors: Michael R Et al.
    Front Cell Dev Biol  2021;9:649433
  2. Arhgef6 (alpha-PIX) cytoskeletal regulator signals to GTPases and Cofilin to couple T cell migration speed and persistence.
    Authors: Johannes Et al.
    J Leukoc Biol  2021;110:839-852
  3. Cyclosporine A inhibits MRTF-SRF signaling through Na+/K+ ATPase inhibition and actin remodeling.
    Authors: Marie Et al.
    FASEB Bioadv  2019;1:561-578
  4. Regional Activation of Myosin II in Cancer Cells Drives Tumor Progression via a Secretory Cross-Talk with the Immune Microenvironment.
    Authors: Georgouli Et al.
    Cell  2019;176:757
  5. The actin filament bundling protein α-actinin-4 actually suppresses actin stress fibers by permitting actin turnover.
    Authors: William M Et al.
    J Biol Chem  2018;293:14520-14533

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