Linopirdine dihydrochloride

Tocris Bioscience | Catalog # 1999

KV7 (KCNQ) channel blocker
Tocris Bioscience

Key Product Details

Description

KV7 (KCNQ) channel blocker

Alternative Names

DuP 996
View all Voltage-gated Potassium Channel Blockers »

Product Description

Linopirdine dihydrochloride is a blocker of KV7 (KCNQ) voltage-gated potassium channels; blocks KV7.1 + 7.3 (KCNQ2 + 3) / M-currents (IC50 = 4 - 7 μM) and KV7.1 (KCNQ1) homomeric channels (IC50 = 8.9 μM). Augments hippocampal ACh release and is a cognitive enhancer following oral administration in vivo.

Product Specifications for Linopirdine dihydrochloride

Molecular Weight

464.39

Formula

C26H21N3O.2HCl

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

1,3-Dihydro-1-phenyl-3,3-bis(4-pyridinylmethyl)-2H-indol-2-one dihydrochloride

CAS Number

113168-57-3

PubChem ID

14209557

InChI Key

ZEVVHCGTTNRYOY-UHFFFAOYSA-N

SMILES

Cl.Cl.O=C1N(C2=CC=CC=C2C1(CC1=CC=NC=C1)CC1=CC=NC=C1)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 46.44 100
DMSO 46.44 100

Preparing Stock Solutions for Linopirdine dihydrochloride

The following data is based on the product molecular weight 464.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.15 mL 10.77 mL 21.53 mL
5 mM 0.43 mL 2.15 mL 4.31 mL
10 mM 0.22 mL 1.08 mL 2.15 mL
50 mM 0.04 mL 0.22 mL 0.43 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 268 publications citing the usage of this product.

Product Documents for Linopirdine dihydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Linopirdine dihydrochloride

For research use only

Citations for Linopirdine dihydrochloride

Customer Reviews for Linopirdine dihydrochloride (1)

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  • Linopirdine proved to be a high quality Kv7 blocker and improves release of several neurotransmitters
    Name: Sadequl Islam
    Species: Human
    Assay Type: In Vitro
    Verified Customer | Posted 10/22/2018
    Our lab is working with Voltage gated potassium channel for a while and I have used a few potent Kv channel blockers to measure out the % blocking showed by them. This product gave reproducible data, stable in biological lab conditions and the work was published. So overall very happy with the purchase of the compound.
    Linopirdine dihydrochloride 1999

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