Home / Active Degraders / MD13

MD13

Catalog #: 7503 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7503/5
MD13 | CAS No. 2758431-97-7 | Active Degraders
1 Image
Description: Potent MIF Degrader (PROTAC®)

Chemical Name: 8-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-N-(4-(7-hydroxy-2-oxo-2H-benzo[e][1,3]oxazin-3(4H)-yl)phenyl)octanamide

Purity: ≥98%

Product Details
Reviews
Biological Activity Technical Data Additional Information Product Datasheets Calculators

Biological Activity

MD13 is a potent macrophage migration inhibitory factor (MIF) Degrader (PROTAC®; DC50 < 100 nM; Dmax = 92% after 6 h). MD13 comprises the cereblon ligand Pomalidomide (Cat. No. 6302) joined by a linker to a MIF inhibitor. MD13 reduces MIF levels, arrests cells at the G2/M phase and inhibits proliferation of A549 lung carcinoma cells. Growth of A549 cell 3D spheroids is also inhibited by MD13.

Negative control MD15 (Cat. No. 7504) and MIF antibodies validated for Simple Western™ (automated Western) instruments and Western Blot also available: Catalog # AF-289-PB and MAB289.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Technical Data

M.Wt:
653.69
Formula:
C35H35N5O8
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2758431-97-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold with kind permission of Professor Dekker.

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for MD13

There are currently no reviews for this product. Be the first to review MD13 and earn rewards!

Have you used MD13?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.