ML 133 hydrochloride
Chemical Name: N-[(4-Methoxyphenyl)methyl]-1-naphthalenemethanamine hydrochloride
Purity: ≥99%
Biological Activity
ML 133 hydrochloride is a selective blocker of inwardly rectifying Kir2 potassium channels (IC50 values are 1.8, 2.8, 2.9 and 4.0 μM at pH 7.4 for mKir2.1, hKir2.6, hKir2.2 and hKir2.3 respectively). Exhibits no effect on rKir1.1 (IC50 > 300 μM); displays weak activity at hKir7.1 and rKir4.1 (IC50 values are 33 and 76 μM).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Mechanisms Underlying Interferon-?-Induced Priming of Microglial Reactive Oxygen Species Production
PLoS ONE, 2016;11(9):e0162497. -
Microglial Kv1.3 Channels and P2Y12 Receptors Differentially Regulate Cytokine and Chemokine Release from Brain Slices of Young Adult and Aged Mice.
Charolidi N, Schilling T, Eder C
PLoS ONE, 2015;10(5):e0128463. -
Responses of rat and mouse primary microglia to pro- and anti-inflammatory stimuli: molecular profiles, K(+) channels and migration
D Lam, S Lively, LC Schlichter
J Neuroinflammation, 2017;14(1):166. -
Selective inhibition of the Kir2 family of inward rectifier potassium channels by a small molecule probe: the discovery, SAR, and pharmacological characterization of ML133.
Wang et al.
ACS Chem.Biol., 2011;6:845 -
A potent and selective small molecule Kir2.1 inhibitor.
Wu et al.
Probe Reports from the NIH Molecular Libraries Pro, 2010;
Product Datasheets
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Citations for ML 133 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for ML 133 hydrochloride include:
4 Citations: Showing 1 - 4
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Roles of Cytokines in the Temporal Changes of Microglial Membrane Currents and Neuronal Excitability and Synaptic Efficacy in ATP-Induced Cortical Injury Model.
Authors: Sung-Joong Et al.
Int J Mol Sci 2021;22
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Comparing Effects of Transforming Growth Factor β1 on Microglia From Rat and Mouse: Transcriptional Profiles and Potassium Channels.
Authors: Lively Et al.
Front Cell Neurosci 2018;12:115
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Complex molecular and functional outcomes of single versus sequential cytokine stimulation of rat microglia.
Authors: Siddiqui Et al.
J Neuroinflammation 2016;13:66
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Expression and contributions of the Kir2.1 inward-rectifier K(+) channel to proliferation, migration and chemotaxis of microglia in unstimulated and anti-inflammatory states.
Authors: Lam and Schlichter
Nat Commun 2015;9:185
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