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ML 281

Catalog #: 4880
1 Citation Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4880/10
4880/50
ML 281 | CAS No. 1404437-62-2 | Other Kinase Inhibitors
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Description: STK33 inhibitor

Chemical Name: N-[2-(3,4-Dihydro-3-oxo-2-quinoxalinyl)-4-(1-methylethyl)phenyl]-2-thiophenecarboxamide

Purity: ≥98%

Product Details
Citations (1)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

ML 281 is an inhibitor of the serine/threonine kinase STK33 (IC50 = 14 nM). Exhibits >700-fold selectivity for STK33 over the structurally related protein kinase A (PKA); also exhibits 550-fold selectivity over Aurora kinase B.

Technical Data

M.Wt:
389.47
Formula:
C22H19N3O2S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1404437-62-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citation for ML 281

The citations listed below are publications that use Tocris products. Selected citations for ML 281 include:

1 Citation: Showing 1 - 1

  1. Pharmacologic Targeting of TFIIH Suppresses KRAS-Mutant Pancreatic Ductal Adenocarcinoma and Synergizes with TRAIL.
    Authors: Christopher J Et al.
    Cancer Res  2022;82:3375-3393

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