Mouse Mrc2 Antibody Summary
Ala31-Ala1413
Accession # AAI16643
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of Mouse Mrc2 by Western Blot. Western blot shows lysates of mouse heart, lung, and kidney tissue. PVDF membrane was probed with 1 µg/mL of Sheep Anti-Mouse Mrc2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF4789) followed by HRP-conjugated Anti-Sheep IgG Secondary Antibody (Catalog # HAF016). A specific band was detected for Mrc2 at approximately 170-180 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 8.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: Mrc2
Mrc2 (macrophage mannose receptor 2; also uPARAP/Endo180) is a 180 kDa member of the mannose receptor family. It is found on fibroblasts, macrophages and endothelial cells. Mrc2 binds and internalizes glycoproteins plus collagen types I and IV. Mouse Mrc2 is a type I transmembrane glycoprotein that is 1479 amino acids (aa) in length. It possesses a 1383 aa extracellular domain (ECD) (aa 31‑1479) and a short 45 aa cytoplasmic tail. The ECD contains eight C‑type lectin domains plus one fibronectin type II domain (aa 181‑229) that binds collagen. There are two splice variants, one which shows an eight aa substitution for aa 173‑1479, and a second that shows a 72 aa substitution for aa 982‑1479. Over aa 311‑413, mouse Mrc2 shares 91% and 97% aa identity with human and rat Mrc2, respectively.
Product Datasheets
Citations for Mouse Mrc2 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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The proteasome modulates endocytosis specifically in glomerular cells to promote kidney filtration
Authors: Sachs, W;Blume, L;Loreth, D;Schebsdat, L;Hatje, F;Koehler, S;Wedekind, U;Sachs, M;Zieliniski, S;Brand, J;Conze, C;Florea, BI;Heppner, F;Krüger, E;Rinschen, MM;Kretz, O;Thünauer, R;Meyer-Schwesinger, C;
Nature communications
Species: Mouse
Sample Types: Cell Lysates, Whole Tissue
Applications: Immunohistochemistry, Western Blot -
Age-dependent regulation of cell-mediated collagen turnover
Authors: Michael J. Podolsky, Christopher D. Yang, Carlos Lizama Valenzuela, Ritwik Datta, Steven K. Huang, Stephen L. Nishimura et al.
JCI Insight
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Tumour cell-derived Wnt7a recruits and activates fibroblasts to promote tumour aggressiveness
Authors: Alexandra Avgustinova, Marjan Iravani, David Robertson, Antony Fearns, Qiong Gao, Pamela Klingbeil et al.
Nature Communications
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