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Mouse/Rat Leptin Quantikine ELISA Kit

Catalog #: MOB00
181 Citations 4 Reviews Datasheet / COA / SDS
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Mouse/Rat Leptin ELISA Standard Curve
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Product Details
Procedure
Citations (181)
FAQs
Reviews (4)
Summary Recovery Linearity Data Examples Product Datasheets Preparation and Storage Background Related Research Areas

Mouse/Rat Leptin Quantikine ELISA Kit Summary

Assay Type
Solid Phase Sandwich ELISA
Format
96-well strip plate
Assay Length
4.5 hours
Sample Type & Volume Required Per Well
Cell Culture Supernates (50 uL), Serum (20 uL), EDTA Plasma (20 uL)
Sensitivity
22 pg/mL
Assay Range
62.5 - 4,000 pg/mL (Cell Culture Supernates, Serum, EDTA Plasma)
Specificity
Natural and recombinant mouse and rat Leptin.  This assay cross-reacts 0.24% with Human Leptin.
Cross-reactivity
< 0.5% cross-reactivity observed with available related molecules.Cross-species reactivity observed with 1 or more species tested.
Interference
Interference observed with 1 or more available related molecules.

Product Summary

The Quantikine Mouse Leptin Immunoassay is a 4.5 hour solid phase ELISA designed to measure soluble mouse leptin in cell culture supernates, serum*, and plasma. It contains recombinant mouse leptin expressed in E. coli and antibodies raised against the recombinant factor. This immunoassay has been shown to quantitate the recombinant mouse leptin accurately. Results obtained measuring natural mouse leptin showed dose-response curves that were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for natural mouse leptin.

*Pregnant mouse serum from the second trimester of pregnancy through post-partum day 1 require acid/urea activation of mouse leptin.

Recovery

The recovery of mouse/rat Leptin spiked to three levels throughout the range of the assay in various matrices was evaluated.

Sample Type Average % Recovery Range %
Mouse Cell Culture Supernates (n=5) 101 85-120
Mouse EDTA Plasma (n=4) 92 78-105
Mouse Heparin Plasma (n=4) 95 81-105
Mouse Serum (n=18) 108 81-122
Rat Cell Culture Supernates (n=4) 114 103-125
Rat EDTA Plasma (n=7) 96 83-114
Rat Serum (n=10) 92 81-115

Linearity

To assess the linearity of the assay, four or more samples containing and/or spiked with high concentrations of mouse/rat Leptin in each matrix were diluted with Calibrator Diluent and then assayed.
Mouse Linearity Curve
Mouse/Rat Leptin/OB ELISA Linearity
Mouse/Rat Leptin/OB ELISA Linearity
Rat Linearity Curve

Scientific Data

N/A Mouse/Rat Leptin ELISA Standard Curve View Larger

Mouse/Rat Leptin ELISA Standard Curve

N/A Mouse/Rat Leptin/OB ELISA Standard Curve View Larger

Mouse/Rat Leptin/OB ELISA Standard Curve

Product Datasheets

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Product Datasheet
COA
SDS

Preparation and Storage

Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Background: Leptin/OB

Leptin is a product of the mouse obese gene. Mice with mutations in the obese gene that block the synthesis of leptin are obese and diabetic, and have reduced activity, metabolism, and body temperature. Rat leptin shares approximately 96% and 82% sequence identity with the mouse and human protein, respectively. The expression of leptin mRNA is restricted to adipose tissue.

Entrez Gene IDs:
3952 (Human); 16846 (Mouse); 25608 (Rat)
Alternate Names:
FLJ94114; LEP; leptin (murine obesity homolog); leptin (obesity homolog, mouse); Leptin; OB; Obese protein; obese, mouse, homolog of; Obesity factor; OBOBS
&#9888; WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Assay Procedure

Refer to the product for complete assay procedure.

Bring all reagents and samples to room temperature before use. It is recommended that all samples, standards, and controls be assayed in duplicate.
  1.   Prepare all reagents, standard dilutions, and samples as directed in the product insert.
  2.   Remove excess microplate strips from the plate frame, return them to the foil pouch containing the desiccant pack, and reseal.
    3. 50 µL Assay Diluent
  3.   Add 50 µL of Assay Diluent to each well.
    4. 50 µL Standard, Control, or Sample
  4.   Add 50 µL of Standard, Control, or sample to each well. Cover with a plate sealer, and incubate at room temperature for 2 hours.
  5.   Aspirate each well and wash, repeating the process 4 times for a total of 5 washes.
    6. 100 µL Conjugate
  6.   Add 100 µL of Conjugate to each well. Cover with a new plate sealer, and incubate at room temperature for 2 hours.
  7.   Aspirate and wash 5 times.
    8. 100 µL Substrate Solution
  8.   Add 100 µL Substrate Solution to each well. Incubate at room temperature for 30 minutes. PROTECT FROM LIGHT.
    9. 100 µL Stop Solution
  9.   Add 100 µL of Stop Solution to each well. Read at 450 nm within 30 minutes. Set wavelength correction to 540 nm or 570 nm.

Citations for Mouse/Rat Leptin Quantikine ELISA Kit

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

181 Citations: Showing 1 - 10
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  1. Group X phospholipase A2 links colonic lipid homeostasis to systemic metabolism via host-microbiota interaction
    Authors: Sato, H;Taketomi, Y;Murase, R;Park, J;Hosomi, K;Sanada, TJ;Mizuguchi, K;Arita, M;Kunisawa, J;Murakami, M;
    Cell reports
    Species: Transgenic Mouse
    Sample Types: Serum
  2. Tanycytic transcytosis inhibition disrupts energy balance, glucose homeostasis and cognitive function in male mice
    Authors: Duquenne, M;Deligia, E;Folgueira, C;Bourouh, C;Caron, E;Pfrieger, F;Schwaninger, M;Nogueiras, R;Annicotte, JS;Imbernon, M;Prévot, V;
    Molecular metabolism
    Species: Mouse
    Sample Types: Serum
  3. Hypothalamic hormone deficiency enables physiological anorexia in ground squirrels during hibernation
    Authors: Mohr, SM;Dai Pra, R;Platt, MP;Feketa, VV;Shanabrough, M;Varela, L;Kristant, A;Cao, H;Merriman, DK;Horvath, TL;Bagriantsev, SN;Gracheva, EO;
    Nature communications
    Species: Squirrel
    Sample Types: Plasma
  4. ANGPTL4 stabilizes atherosclerotic plaques and modulates the phenotypic transition of vascular smooth muscle cells through KLF4 downregulation
    Authors: DI Cho, MJ Ahn, HH Cho, M Cho, JH Jun, BG Kang, SY Lim, SJ Yoo, MR Kim, HS Kim, SJ Lee, LT Dat, C Lee, YS Kim, Y Ahn
    Experimental & Molecular Medicine, 2023-02-13;0(0):.
    Species: Mouse
    Sample Types: Plasma
  5. Hepatic phosphatidylcholine catabolism driven by PNPLA7 and PNPLA8 supplies endogenous choline to replenish the methionine cycle with methyl groups
    Authors: T Hirabayash, M Kawaguchi, S Harada, M Mouri, R Takamiya, Y Miki, H Sato, Y Taketomi, K Yokoyama, T Kobayashi, SM Tokuoka, Y Kita, E Yoda, S Hara, K Mikami, Y Nishito, N Kikuchi, R Nakata, M Kaneko, H Kiyonari, K Kasahara, T Aiba, K Ikeda, T Soga, M Kurano, Y Yatomi, M Murakami
    Cell Reports, 2023-01-30;42(2):111940.
    Species: Mouse
    Sample Types: Serum
  6. Ceruloplasmin-Deficient Mice Show Dysregulation of Lipid Metabolism in Liver and Adipose Tissue Reduced by a Protein Replacement
    Authors: S Raia, A Conti, A Zanardi, B Ferrini, GM Scotti, E Gilberti, G De Palma, S David, M Alessio
    International Journal of Molecular Sciences, 2023-01-06;24(2):.
    Species: Mouse
    Sample Types: Tissue Homogenates
  7. The mitochondrial UPR regulator ATF5 promotes intestinal barrier function via control of the satiety response
    Authors: D Chamseddin, SA Mahmud, AK Westfall, TA Castoe, RE Berg, MW Pellegrino
    Cell Reports, 2022-12-13;41(11):111789.
    Species: Mouse
    Sample Types: Plasma
  8. Opposing Actions of TLR2 and TLR4 in Adipocyte Differentiation and Mature-Onset Obesity
    Authors: N Cuesta, S Fernández-, C Punzón, C Moreno, B Barrocal, V Sreeramkum, M Desco, M Fresno
    International Journal of Molecular Sciences, 2022-12-10;23(24):.
    Species: Mouse
    Sample Types: Serum
  9. Ras drives malignancy through stem cell crosstalk with the microenvironment
    Authors: S Yuan, KS Stewart, Y Yang, MD Abdusselam, SM Parigi, TY Feinberg, K Tumaneng, H Yang, JM Levorse, L Polak, D Ng, E Fuchs
    Nature, 2022-11-30;0(0):.
    Species: Mouse
    Sample Types: Plasma
  10. Blockade of CXXC5-dishevelled interaction inhibits adipogenic differentiation, obesity, and insulin resistance in mice
    Authors: SH Seo, D Lee, SH Lee, KY Choi
    Scientific Reports, 2022-11-30;12(1):20669.
    Species: Mouse
    Sample Types: Serum
  11. Pancreastatin inhibitor PSTi8 balances energy homeostasis by attenuating adipose tissue inflammation in high fat diet fed mice
    Authors: UK Goand, S Verma, AP Gupta, R Garg, S Dadge, JR Gayen
    Peptides, 2022-11-11;159(0):170902.
    Species: Mouse
    Sample Types: Serum
  12. Discovery of PPARgamma and glucocorticoid receptor dual agonists to promote the adiponectin and leptin biosynthesis in human bone marrow mesenchymal stem cells
    Authors: S Ahn, M Ahn, S Park, S An, IG Park, SY Hwang, J Gong, S Oh, SH Jin, HJ Kim, JH Cheong, Y Byun, M Noh
    European Journal of Medicinal Chemistry, 2022-11-10;245(0):114927.
    Species: Mouse
    Sample Types: Serum
  13. REDD1 promotes obesity-induced metabolic dysfunction via atypical NF-kappaB activation
    Authors: DK Lee, T Kim, J Byeon, M Park, S Kim, J Kim, S Choi, G Lee, C Park, KW Lee, YJ Kwon, JH Lee, YG Kwon, YM Kim
    Nature Communications, 2022-10-22;13(1):6303.
    Species: Mouse
    Sample Types: Plasma
  14. Metformin Mitigated Obesity-Driven Cancer Aggressiveness in Tumor-Bearing Mice
    Authors: CJ Chen, CC Wu, CY Chang, JR Li, YC Ou, WY Chen, SL Liao, JD Wang
    International Journal of Molecular Sciences, 2022-08-15;23(16):.
    Species: Mouse
    Sample Types: Plasma
  15. Breast Milk MicroRNAs Related to Leptin and Adiponectin Function Can Be Modulated by Maternal Diet and Influence Offspring Phenotype in Rats
    Authors: M Alonso-Ber, A Asensio, A Palou-Marc, J Sánchez, A Palou, F Serra, M Palou
    International Journal of Molecular Sciences, 2022-06-29;23(13):.
    Species: Rat
    Sample Types: Plasma
  16. beta-Carotene from the Alga Dunaliella bardawil Decreases Gene Expression of Adipose Tissue Macrophage Recruitment Markers and Plasma Lipid Concentrations in Mice Fed a High-Fat Diet
    Authors: N Melnikov, Y Kamari, M Kandel-Kfi, I Barshack, A Ben-Amotz, D Harats, A Shaish, A Harari
    Marine Drugs, 2022-06-29;20(7):.
    Species: Mouse
    Sample Types: Plasma
  17. Perinatal Treatment with Leptin, but Not Celastrol, Protects from Metabolically Obese, Normal-Weight Phenotype in Rats
    Authors: B Reynés, M Cifre, A Palou, P Oliver
    Nutrients, 2022-05-29;14(11):.
    Species: Rat
    Sample Types: Serum
  18. Maternal Consumption of a Cafeteria Diet during Lactation Leads to Altered Diet-Induced Thermogenesis in Descendants after Exposure to a Western Diet in Adulthood
    Authors: CA Pomar, C Picó, A Palou, J Sánchez
    Nutrients, 2022-05-07;14(9):.
    Species: Rat
    Sample Types: Plasma
  19. Bifidobacterium animalis ssp. lactis MG741 Reduces Body Weight and Ameliorates Nonalcoholic Fatty Liver Disease via Improving the Gut Permeability and Amelioration of Inflammatory Cytokines
    Authors: MH Do, MJ Oh, HB Lee, CH Kang, G Yoo, HY Park
    Nutrients, 2022-05-07;14(9):.
    Species: Mouse
    Sample Types: Whole Tissue
  20. Central deficiency of IL-6Ra in mice impairs glucose-stimulated insulin secretion
    Authors: AD McNeilly, A Yianakas, JG Gallagher, J Tarlton, ML Ashford, RJ McCrimmon
    Molecular Metabolism, 2022-04-22;61(0):101488.
    Species: Mouse
    Sample Types: Plasma
  21. Structural and immunoendocrine remodeling in gut, pancreas and thymus in weaning rats fed powdered milk diets rich in Maillard reactants
    Authors: J Dereke, E Ekblad, B Weström, C Erlanson-A, M Landin-Ols, I Sjöholm, M Hillman
    Scientific Reports, 2022-03-08;12(1):4039.
    Species: Rat
    Sample Types: Plasma
  22. Roux-En-Y Gastric Bypass (RYGB) Surgery during High Liquid Sucrose Diet Leads to Gut Microbiota-Related Systematic Alterations
    Authors: L Zizmare, CN Boyle, S Buss, S Louis, L Kuebler, K Mulay, R Krüger, L Steinhauer, I Mack, M Rodriguez, K Herfert, Y Ritze, C Trautwein
    International Journal of Molecular Sciences, 2022-01-20;23(3):.
    Species: Rat
    Sample Types: Feces
  23. Combined Phyllostachys pubescens and Scutellaria baicalensis Prevent High-Fat Diet-Induced Obesity via Upregulating Thermogenesis and Energy Expenditure by UCP1 in Male C57BL/6J Mice
    Authors: YY Sung, SH Kim, DS Kim
    Nutrients, 2022-01-19;14(3):.
    Species: Mouse
    Sample Types: Serum
  24. Loss of the Protective Effect of Estrogen Contributes to Maternal Gestational Hypertension-Induced Hypertensive Response Sensitization Elicited by Postweaning High-Fat Diet in Female Offspring
    Authors: B Xue, Y Yu, TG Beltz, F Guo, SG Wei, AK Johnson
    Journal of the American Heart Association, 2022-01-11;11(2):e023685.
    Species: Rat
    Sample Types: Plasma
  25. High-fat western diet-consumption alters crystalline silica-induced serum adipokines, inflammatory cytokines and arterial blood flow in the F344 rat
    Authors: JA Thompson, K Krajnak, RA Johnston, ML Kashon, W McKinney, JS Fedan
    Toxicology reports, 2021-12-07;9(0):12-21.
    Species: Rat
    Sample Types: Serum
  26. Myo-Inositol Supplementation in Suckling Rats Protects against Adverse Programming Outcomes on Hypothalamic Structure Caused by Mild Gestational Calorie Restriction, Partially Comparable to Leptin Effects
    Authors: P Castillo, M Palou, ZX Yau-Qiu, AM Rodríguez, A Palou, C Picó
    Nutrients, 2021-09-18;13(9):.
    Species: Rat
    Sample Types: Plasma
  27. Maternal Angiotensin II-Induced Hypertension Sensitizes Postweaning High-Fat Diet-Elicited Hypertensive Response Through Increased Brain Reactivity in Rat Offspring
    Authors: B Xue, Y Yu, TG Beltz, F Guo, RB Felder, SG Wei, A Kim Johnso
    Journal of the American Heart Association, 2021-09-06;0(0):e022170.
    Species: Rat
    Sample Types: Plasma
  28. Sexual Dimorphism in Changes That Occur in Tissues, Organs and Plasma during the Early Stages of Obesity Development
    Authors: P Dhanraj, MB van Heerde, MS Pepper, MA Ambele
    Biology, 2021-07-28;10(8):.
    Species: Mouse
    Sample Types: Plasma
  29. Ectopic Leptin Production by Intraocular Pancreatic Islet Organoids Ameliorates the Metabolic Phenotype of ob/ob Mice
    Authors: B Leibiger, T Moede, I Valladolid, M Paschen, M Visa, IB Leibiger, PO Berggren
    Metabolites, 2021-06-14;11(6):.
    Species: Mouse
    Sample Types: Cell Culture Superantes
  30. Dopamine D2 receptor agonist, bromocriptine, remodels adipose tissue dopaminergic signalling and upregulates catabolic pathways, improving metabolic profile in type 2 diabetes
    Authors: G Tavares, D Marques, C Barra, D Rosendo-Si, A Costa, T Rodrigues, P Gasparini, BF Melo, JF Sacramento, R Seiça, SV Conde, P Matafome
    Molecular Metabolism, 2021-04-29;0(0):101241.
    Species: Rat
    Sample Types: Plasma
  31. Rat Milk and Plasma Immunological Profile throughout Lactation
    Authors: B Grases-Pin, M Abril-Gil, P Torres-Cas, M Castell, MJ Rodríguez-, FJ Pérez-Cano, À Franch
    Nutrients, 2021-04-11;13(4):.
    Species: Rat
    Sample Types: Serum
  32. Selenium supplementation inhibits IGF-1 signaling and confers methionine restriction-like healthspan benefits to mice
    Authors: JD Plummer, SD Postnikoff, JK Tyler, JE Johnson
    Elife, 2021-03-30;10(0):.
    Species: Mouse
    Sample Types: Plasma
  33. The effect of calorie intake, fasting, and dietary composition on metabolic health and gut microbiota in mice
    Authors: Z Zhang, X Chen, YJ Loh, X Yang, C Zhang
    Bmc Biology, 2021-03-19;19(1):51.
    Species: Mouse
    Sample Types: Serum
  34. Maternal and Postnatal High Linoleic Acid Diet Impacts Lipid Metabolism in Adult Rat Offspring in a Sex-Specific Manner
    Authors: N Shrestha, J Vidimce, OJ Holland, JSM Cuffe, BR Beck, AV Perkins, AJ McAinch, DH Hryciw
    International Journal of Molecular Sciences, 2021-03-14;22(6):.
    Species: Rat
    Sample Types: Plasma
  35. Diet-induced obesity leads to alterations in behavior and gut microbiota composition in mice
    Authors: REM Júnior, LM de Carvalh, D Carlos Dos, GD Cassali, AMC Faria, TU Maioli, ALB Godard
    The Journal of nutritional biochemistry, 2021-03-08;0(0):108622.
    Species: Mouse
    Sample Types: Plasma
  36. Impact of SGLT-2 Inhibition on Cardiometabolic Abnormalities in a Rat Model of Polycystic Ovary Syndrome
    Authors: JE Pruett, ED Torres Fer, SJ Everman, RM Vinson, K Davenport, MK Logan, SA Ye, DG Romero, LL Yanes Card
    International Journal of Molecular Sciences, 2021-03-04;22(5):.
    Species: Rat
    Sample Types: Plasma
  37. Active integrins regulate white adipose tissue insulin sensitivity and brown fat thermogenesis
    Authors: FJ Ruiz-Ojeda, J Wang, T Bäcker, M Krueger, S Zamani, S Rosowski, T Gruber, Y Onogi, A Feuchtinge, TJ Schulz, R Fässler, TD Müller, C García-Các, M Meier, M Blüher, S Ussar
    Molecular Metabolism, 2021-01-07;45(0):101147.
    Species: Mouse
    Sample Types: Serum
  38. Repetitive Ozone Exposures and Evaluation of Pulmonary Inflammation and Remodeling in Diabetic Mouse Strains
    Authors: JG Wagner, CE Barkauskas, A Vose, RP Lewandowsk, JR Harkema, RM Tighe
    Environmental health perspectives, 2020-11-30;128(11):117009.
    Species: Mouse
    Sample Types: Plasma
  39. Caloric restriction modulates the monoaminergic system and metabolic hormones in aged rats
    Authors: M Portero-Tr, D Rojic-Beck, C Vega-Carba, G Guillazo-B, A Vale-Martí, M Martí-Nico
    Sci Rep, 2020-11-09;10(1):19299.
    Species: Rat
    Sample Types: Plasma
  40. Anti-Obesity Effects of a Prunus persica and Nelumbo nucifera Mixture in Mice Fed a High-Fat Diet
    Authors: J Song, J Kim, HJ Park, H Kim
    Nutrients, 2020-11-04;12(11):.
    Species: Mouse
    Sample Types: Serum
  41. Elevated blood pressure in high-fat diet-exposed low birthweight rat offspring is most likely caused by elevated glucocorticoid levels�due to abnormal pituitary negative feedback
    Authors: T Nemoto, T Nakakura, Y Kakinuma
    PLoS ONE, 2020-08-27;15(8):e0238223.
    Species: Rat
    Sample Types: Plasma
  42. Leptin Distribution in Rat Foetal and Extraembryonic Tissues in Late Gestation: A Physiological View of Amniotic Fluid Leptin
    Authors: ZX Yau-Qiu, C Picó, AM Rodríguez, A Palou
    Nutrients, 2020-08-21;12(9):.
    Species: Rat
    Sample Types: Tissue Homogenates
  43. High-fat diet from parental generation exaggerates body and adipose tissue weights in pregnant offspring
    Authors: FT Spradley
    PLoS ONE, 2020-08-20;15(8):e0237708.
    Species: Rat
    Sample Types: Plasma
  44. The Intake of a Cafeteria Diet in Nursing Rats Alters the Breast Milk Concentration of Proteins Important for the Development of Offspring
    Authors: CA Pomar, J Sánchez, A Palou
    Nutrients, 2020-08-17;12(8):.
    Species: Rat
    Sample Types: Breast Milk
  45. Sodium glucose co-transporter 2 inhibition reduces succinate levels in diabetic mice
    Authors: LY Herat, NC Ward, AL Magno, EP Rakoczy, MG Kiuchi, MP Schlaich, VB Matthews
    World J. Gastroenterol., 2020-06-21;26(23):3225-3235.
    Species: Mouse
    Sample Types: Serum
  46. Effect of waterpipe tobacco smoke exposure on the development of metabolic syndrome in adult male rats
    Authors: NA Al-Sawalha, Y Almahmmod, MS Awawdeh, KH Alzoubi, OF Khabour
    PLoS ONE, 2020-06-19;15(6):e0234516.
    Species: Rat
    Sample Types: Serum
  47. Comparison of cricket diet with peanut-based and milk-based diets in the recovery from protein malnutrition in mice and the impact on growth, metabolism and immune function
    Authors: RS Bergmans, M Nikodemova, VJ Stull, A Rapp, KMC Malecki
    PLoS ONE, 2020-06-11;15(6):e0234559.
    Species: Mouse
    Sample Types: Serum
  48. Anomalous AMPK-regulated angiotensin AT1R expression and SIRT1-mediated mitochondrial biogenesis at RVLM in hypertension programming of offspring to maternal high fructose exposure
    Authors: YM Chao, KLH Wu, PC Tsai, YL Tain, S Leu, WC Lee, JYH Chan
    J. Biomed. Sci., 2020-05-23;27(1):68.
    Species: Rat
    Sample Types: Plasma
  49. Secreted Phospholipase PLA2G2D Contributes to Metabolic Health by Mobilizing ?3 Polyunsaturated Fatty Acids in WAT
    Authors: H Sato, Y Taketomi, Y Miki, R Murase, K Yamamoto, M Murakami
    Cell Rep, 2020-05-05;31(5):107579.
    Species: Mouse
    Sample Types: Serum
  50. Decreased brain and muscle ARNT-like protein 1 expression mediated the contribution of hyperandrogenism to insulin resistance in polycystic ovary syndrome
    Authors: J Zhai, S Li, M Hu, F Di, J Liu, Y Du
    Reprod. Biol. Endocrinol., 2020-04-25;18(1):32.
    Species: Rat
    Sample Types: Serum
  51. Retinal innervation tunes circuits that drive nonphotic entrainment to food
    Authors: DC Fernandez, R Komal, J Langel, J Ma, PQ Duy, MA Penzo, H Zhao, S Hattar
    Nature, 2020-04-22;581(7807):194-198.
    Species: Mouse
    Sample Types: Plasma
  52. Effects of Cabbage-Apple Juice Fermented by Lactobacillus plantarum EM on Lipid Profile Improvement and Obesity Amelioration in Rats
    Authors: S Park, HK Son, HC Chang, JJ Lee
    Nutrients, 2020-04-18;12(4):.
    Species: Rat
    Sample Types: Serum
  53. Leptin mediates postprandial increases in body temperature through hypothalamus-adrenal medulla-adipose tissue crosstalk
    Authors: RJ Perry, K Lyu, A Rabin-Cour, J Dong, X Li, Y Yang, H Qing, A Wang, X Yang, GI Shulman
    J. Clin. Invest., 2020-04-01;130(4):2001-2016.
    Species: Rat
    Sample Types: Plasma
  54. Postprandial Hyperglycemia Stimulates Neuroglial Plasticity in Hypothalamic POMC Neurons after a Balanced Meal
    Authors: D Nuzzaci, C Cansell, F Liénard, E Nédélec, S Ben Fradj, J Castel, E Foppen, R Denis, D Grouselle, A Laderrière, A Lemoine, A Mathou, V Tolle, T Heurtaux, X Fioramonti, E Audinat, L Pénicaud, JL Nahon, C Rovère, A Benani
    Cell Rep, 2020-03-03;30(9):3067-3078.e5.
    Species: Mouse
    Sample Types: Plasma
  55. BRS3 in both MC4R- and SIM1-expressing neurons regulates energy homeostasis in mice
    Authors: C Xiao, N Liu, H Province, RA Piñol, O Gavrilova, ML Reitman
    Mol Metab, 2020-02-29;36(0):100969.
    Species: Mouse
    Sample Types: Whole Blood
  56. Therapeutic Effects of Lithospermate B Complexed with Mg2+ or Zn2+ on Metabolic Syndrome Induced in Rats Fed with High-Fat Diet
    Authors: SK Hsieh, NH Lin, YJ Chen, MR Lee, WY Chen, JTC Tzen
    Molecules, 2020-02-22;25(4):.
    Species: Rat
    Sample Types: Whole Blood
  57. Roles of the vestibular system in obesity and impaired glucose metabolism in high-fat diet-fed mice
    Authors: N Kawao, Y Takafuji, M Ishida, K Okumoto, H Morita, M Muratani, H Kaji
    PLoS ONE, 2020-02-03;15(2):e0228685.
    Species: Mouse
    Sample Types: Serum
  58. WWP1 knockout in mice exacerbates obesity-related phenotypes in white adipose tissue but improves whole body glucose metabolism
    Authors: S Hoshino, M Kobayashi, R Tagawa, R Konno, T Abe, K Furuya, K Miura, H Wakasawa, N Okita, Y Sudo, Y Mizunoe, Y Nakagawa, T Nakamura, H Kawabe, Y Higami
    FEBS Open Bio, 2020-02-03;0(0):.
    Species: Mouse
    Sample Types: Plasma
  59. Role of GDF15 in active lifestyle induced metabolic adaptations and acute exercise response in mice
    Authors: CI Gil, M Ost, J Kasch, S Schumann, S Heider, S Klaus
    Sci Rep, 2019-12-27;9(1):20120.
    Species: Mouse
    Sample Types: Plasma
  60. Exercise reduces inflammatory cell production and cardiovascular inflammation via instruction of hematopoietic progenitor cells
    Authors: V Frodermann, D Rohde, G Courties, N Severe, MJ Schloss, H Amatullah, CS McAlpine, S Cremer, FF Hoyer, F Ji, ID van Koever, F Herisson, L Honold, GS Masson, S Zhang, J Grune, Y Iwamoto, SP Schmidt, GR Wojtkiewic, IH Lee, K Gustafsson, G Pasterkamp, SCA de Jager, RI Sadreyev, J MacFadyen, P Libby, P Ridker, DT Scadden, K Naxerova, KL Jeffrey, FK Swirski, M Nahrendorf
    Nat. Med., 2019-11-07;25(11):1761-1771.
    Species: Mouse
    Sample Types: Plasma
  61. Roles of leptin in the recovery of muscle and bone by reloading after mechanical unloading in high fat diet-fed obese mice
    Authors: N Kawao, M Ishida, H Kaji
    PLoS ONE, 2019-10-24;14(10):e0224403.
    Species: Mouse
    Sample Types: Serum
  62. The Preventive Effects of Greenshell Mussel (Perna canaliculus) on Early-Stage Metabolic Osteoarthritis in Rats with Diet-Induced Obesity
    Authors: P Siriarchav, MC Kruger, MR Miller, HS Tian, FM Wolber
    Nutrients, 2019-07-15;11(7):.
    Species: Rat
    Sample Types: Plasma
  63. Metabolic and behavioral parameters of mice with reduced expression of Syndecan-1
    Authors: C Gougoula, AP Bielfeld, SJ Pour, M Sager, JS Krüssel, WPM Benten, DM Baston-Büs
    PLoS ONE, 2019-07-12;14(7):e0219604.
    Species: Mouse
    Sample Types: Plasma
  64. A diet including xanthan gum triggers a pro-inflammatory response in Wistar rats inoculated with Walker 256 cells
    Authors: AB Silva Risc, NIP Neto, K Gascho, M Carnier, DA de Miranda, FP Silva, VT Boldarine, M Seelaender, EB Ribeiro, LM Oyama, CM Oller do N
    PLoS ONE, 2019-06-18;14(6):e0218567.
    Species: Rat
    Sample Types: Serum
  65. Elevated leptin levels induce inflammation through IL-6 in skeletal muscle of aged female rats
    Authors: R Tazawa, K Uchida, H Fujimaki, M Miyagi, G Inoue, H Sekiguchi, K Murata, K Takata, A Kawakubo, M Takaso
    BMC Musculoskelet Disord, 2019-05-10;20(1):199.
    Species: Rat
    Sample Types: Plasma
  66. High Protein Diet Induces Oxidative Stress in Rat Cerebral Cortex and Hypothalamus
    Authors: E ?ebrowska, M Maciejczyk, M ?endzian-P, A Zalewska, A Chabowski
    Int J Mol Sci, 2019-03-28;20(7):.
    Species: Rat
    Sample Types: Plasma
  67. Adipose Lipocalin 2 overexpression protects against age-related decline in thermogenic function of adipose tissue and metabolic deterioration
    Authors: JA Deis, H Guo, Y Wu, C Liu, DA Bernlohr, X Chen
    Mol Metab, 2019-03-20;0(0):.
    Species: Mouse
    Sample Types: Serum
  68. Chronically reduced BDNF levels increase oxidative stress in epididymal, but not subcutaneous, adipose tissue following high sucrose and high fat diets fed mice
    Authors: A Bodur, ? ?nce, C Kahraman, ? Abidin, S Aydin-Abid, A Alver
    Arch. Biochem. Biophys., 2019-02-21;0(0):.
    Species: Mouse
    Sample Types: Serum
  69. Sustained Intermittent Hypoxemia Induces Adiponectin Oligomers Redistribution and a Tissue-Specific Modulation of Adiponectin Receptor in Mice
    Authors: M Pierard, A Tassin, S Conotte, K Zouaoui Bo, A Legrand
    Front Physiol, 2019-02-08;10(0):68.
    Species: Mouse
    Sample Types: Plasma
  70. Cardiac leptin overexpression in the context of acute MI and reperfusion potentiates myocardial remodeling and left ventricular dysfunction
    Authors: D Kain, AJ Simon, A Greenberg, D Ben Zvi, B Gilburd, J Schneiderm
    PLoS ONE, 2018-10-12;13(10):e0203902.
    Species: Mouse
    Sample Types: Plasma
  71. Hesperidin and capsaicin, but not the combination, prevent hepatic steatosis and other metabolic syndrome-related alterations in western diet-fed rats
    Authors: A Mosqueda-S, J Sánchez, B Reynés, M Palou, MP Portillo, A Palou, C Picó
    Sci Rep, 2018-10-10;8(1):15100.
    Species: Rat
    Sample Types: Plasma
  72. Baicalin Exerts Anti-Airway Inflammation and Anti-Remodelling Effects in Severe Stage Rat Model of Chronic Obstructive Pulmonary Disease
    Authors: G Wang, N Mohammadtu, Y Lv, H Zhang, J Sun, J Dong
    Evid Based Complement Alternat Med, 2018-10-08;2018(0):7591348.
    Species: Rat
    Sample Types: Serum
  73. Leptin Increases Particle-Induced Osteolysis in Female ob/ob Mice
    Authors: KA Philbrick, AJ Branscum, CP Wong, RT Turner, UT Iwaniec
    Sci Rep, 2018-10-04;8(1):14790.
    Species: Mouse
    Sample Types: Serum
  74. Quantification of the constituents of the traditional Korea medicine, Samryeongbaekchul-san, and assessment of its antiadipogenic effect
    Authors: CS Seo, SR Yoo, SJ Jeong, H Ha
    Saudi Pharm J, 2018-09-11;27(1):145-153.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  75. Disentangling Host-Microbiota Regulation of Lipid Secretion by Enterocytes: Insights from Commensals Lactobacillus paracasei and Escherichia coli
    Authors: A Tazi, JR Araujo, C Mulet, ET Arena, G Nigro, T Pédron, PJ Sansonetti
    MBio, 2018-09-04;9(5):.
    Species: Mouse
    Sample Types: Serum
  76. Loss of Nucleobindin-2 Causes Insulin Resistance in Obesity without Impacting Satiety or Adiposity
    Authors: A Ravussin, YH Youm, J Sander, S Ryu, K Nguyen, L Varela, GI Shulman, S Sidorov, TL Horvath, JL Schultze, VD Dixit
    Cell Rep, 2018-07-31;24(5):1085-1092.e6.
    Species: Mouse
    Sample Types: Serum
  77. The exposure to uteroplacental insufficiency is associated with activation of unfolded protein response in postnatal life
    Authors: A Deodati, J Argemí, D Germani, A Puglianiel, A Alisi, C De Stefani, R Ferrero, V Nobili, T Aragón, S Cianfarani
    PLoS ONE, 2018-06-13;13(6):e0198490.
    Species: Rat
    Sample Types: Plasma
  78. Tumor-independent host secretomes induced by angiogenesis and immune-checkpoint inhibitors
    Authors: M Mastri, CR Lee, A Tracz, RS Kerbel, M Dolan, Y Shi, JML Ebos
    Mol. Cancer Ther., 2018-04-25;0(0):.
    Species: Mouse
    Sample Types: Plasma
  79. Leptin stimulates aromatase in the growth plate: limiting catch-up growth efficiency
    Authors: M Masarwi, R Shamir, M Phillip, G Gat-Yablon
    J. Endocrinol., 2018-04-03;0(0):.
    Species: Rat
    Sample Types: Serum
  80. Predominant gut Lactobacillus murinus strain mediates anti-inflammaging effects in calorie-restricted mice
    Authors: F Pan, L Zhang, M Li, Y Hu, B Zeng, H Yuan, L Zhao, C Zhang
    Microbiome, 2018-03-21;6(1):54.
    Species: Mouse
    Sample Types: Serum
  81. Deletion of the cold thermoreceptor TRPM8 increases heat loss and food intake leading to reduced body temperature and obesity in mice
    Authors: A Reimúndez, C Fernández-, G García, R Fernández, P Ordás, R Gallego, JL Pardo-Vazq, V Arce, F Viana, R Señarís
    J. Neurosci., 2018-03-12;0(0):.
    Species: Mouse
    Sample Types: Serum
  82. Intermittent hypoxia suppression of growth hormone and insulin-like growth factor-I in the neonatal rat liver
    Authors: C Cai, T Ahmad, GB Valencia, JV Aranda, J Xu, KD Beharry
    Growth Horm. IGF Res., 2018-03-08;0(0):.
    Species: Rat
    Sample Types: Tissue Homogenates
  83. Nrf2 prevents Notch-induced insulin resistance and tumorigenesis in mice
    Authors: DV Chartoumpe, Y Yagishita, M Fazzari, DL Palliyagur, UN Rao, A Zaravinos, NK Khoo, FJ Schopfer, KR Weiss, GK Michalopou, I Sipula, RM O'Doherty, TW Kensler, N Wakabayash
    JCI Insight, 2018-03-08;3(5):.
    Species: Mouse
    Sample Types: Plasma
  84. Increased Ifi202b/IFI16 expression stimulates adipogenesis in mice and humans
    Authors: M Stadion, K Schwerbel, A Graja, C Baumeier, M Rödiger, W Jonas, C Wolfrum, H Staiger, A Fritsche, HU Häring, N Klöting, M Blüher, P Fischer-Po, TJ Schulz, HG Joost, H Vogel, A Schürmann
    Diabetologia, 2018-02-24;0(0):.
    Species: Mouse
    Sample Types: Plasma
  85. Differential effect of dietary vitamin D supplementation on natural killer cell activity in lean and obese mice
    Authors: GY Lee, CY Park, KS Cha, SE Lee, M Pae, SN Han
    J. Nutr. Biochem., 2018-01-31;55(0):178-184.
    Species: Mouse
    Sample Types: Serum
  86. The antidepressant fluoxetine acts on energy balance and leptin sensitivity via BDNF
    Authors: G Scabia, I Barone, M Mainardi, G Ceccarini, M Scali, E Buzzigoli, A Dattilo, P Vitti, A Gastaldell, F Santini, T Pizzorusso, L Maffei, M Maffei
    Sci Rep, 2018-01-29;8(1):1781.
    Species: Mouse
    Sample Types: Plasma
  87. Leptin-induced basal Akt phosphorylation and its implication in exercise-mediated improvement of insulin sensitivity
    Authors: X Zheng, S Niu
    Biochem. Biophys. Res. Commun., 2017-12-30;0(0):.
    Species: Rat
    Sample Types: Serum
  88. Adipose Tissue Deficiency of Hormone-Sensitive Lipase Causes Fatty Liver in Mice
    Authors: B Xia, GH Cai, H Yang, SP Wang, GA Mitchell, JW Wu
    PLoS Genet., 2017-12-12;13(12):e1007110.
    Species: Mouse
    Sample Types: Plasma
  89. Adiponectin release and insulin receptor targeting share trans-Golgi-dependent endosomal trafficking routes
    Authors: M Rödiger, MW Werno, I Wilhelmi, C Baumeier, D Hesse, N Wettschure, S Offermanns, K Song, M Krau beta, A Schürmann
    Mol Metab, 2017-11-22;0(0):.
    Species: Mouse
    Sample Types: Tissue Homogenates
  90. High-fat diet-induced obesity and insulin resistance are characterized by differential beta oscillatory signaling of the limbic cortico-basal ganglia loop
    Authors: L Maurer, H Tang, JK Haumesser, J Altschüler, AA Kühn, J Spranger, C van Riesen
    Sci Rep, 2017-11-14;7(1):15555.
    Species: Mouse
    Sample Types: Serum
  91. Specific Features of the Hypothalamic Leptin Signaling Response to Cold Exposure Are Reflected in Peripheral Blood Mononuclear Cells in Rats and Ferrets
    Authors: B Reynés, M Klein Haze, E García-Rui, J Keijer, P Oliver, A Palou
    Front Physiol, 2017-08-15;8(0):581.
    Species: Rat
    Sample Types: Serum
  92. Elevated hepatic DPP4 activity promotes insulin resistance and non-alcoholic fatty liver disease
    Authors: C Baumeier, L Schlüter, S Saussentha, T Laeger, M Rödiger, SA Alaze, L Fritsche, HU Häring, N Stefan, A Fritsche, RW Schwenk, A Schürmann
    Mol Metab, 2017-08-04;6(10):1254-1263.
    Species: Mouse
    Sample Types: Plasma
  93. Voluntary physical activity counteracts the proliferative tumor growth microenvironment created by adipose tissue via high-fat diet feeding in female rats
    Authors: CF Theriau, MK Connor
    Physiol Rep, 2017-07-01;5(13):.
    Species: Rat
    Sample Types: Tissue Culture Supernates
  94. Effects of Low-Dose Developmental Bisphenol A Exposure on Metabolic Parameters and Gene Expression in Male and Female Fischer 344 Rat Offspring
    Authors: MH Lejonklou, L Dunder, E Bladin, V Pettersson, M Rönn, L Lind, TB Waldén, PM Lind
    Environ. Health Perspect., 2017-06-28;125(6):067018.
    Species: Rat
    Sample Types: Plasma
  95. The SGLT2 inhibitor empagliflozin improves the primary diabetic complications in ZDF rats
    Authors: S Steven, M Oelze, A Hanf, S Kröller-Sc, F Kashani, S Roohani, P Welschof, M Kopp, U Gödtel-Arm, N Xia, H Li, E Schulz, KJ Lackner, L Wojnowski, SP Bottari, P Wenzel, E Mayoux, T Münzel, A Daiber
    Redox Biol, 2017-06-22;13(0):370-385.
    Species: Rat
    Sample Types: Serum
  96. Effects of mild calorie restriction on lipid metabolism and inflammation in liver and adipose tissue
    Authors: CY Park, S Park, MS Kim, HK Kim, SN Han
    Biochem. Biophys. Res. Commun., 2017-06-17;0(0):.
    Species: Mouse
    Sample Types: Serum
  97. Effects of epigallocatechin-3-gallate on thermogenesis and mitochondrial biogenesis in brown adipose tissues of diet-induced obese mice
    Authors: MS Lee, Y Shin, S Jung, Y Kim
    Food Nutr Res, 2017-05-26;61(1):1325307.
    Species: Mouse
    Sample Types: Plasma
  98. ASK1 (MAP3K5) is transcriptionally upregulated by E2F1 in adipose tissue in obesity, molecularly defining a human dys-metabolic obese phenotype
    Authors: Y Haim, M Blüher, D Konrad, N Goldstein, N Klöting, I Harman-Boe, B Kirshtein, D Ginsberg, T Tarnovscki, Y Gepner, I Shai, A Rudich
    Mol Metab, 2017-05-06;6(7):725-736.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  99. Further investigation of phenotypes and confounding factors of progressive ratio performance and feeding behavior in the BACHD rat model of Huntington disease
    Authors: EK Clemensson, LE Clemensson, B Fabry, O Riess, HP Nguyen
    PLoS ONE, 2017-03-08;12(3):e0173232.
    Species: Rat
    Sample Types: Serum
  100. Prolonged high-fat diet induces gradual and fat depot-specific DNA methylation changes in adult mice
    Authors: RA Zwamborn, RC Slieker, PC Mulder, I Zoetemelk, L Verschuren, HE Suchiman, KH Toet, S Droog, PE Slagboom, T Kooistra, R Kleemann, BT Heijmans
    Sci Rep, 2017-03-03;7(0):43261.
    Species: Mouse
    Sample Types: Plasma
  101. Sterol regulatory element-binding protein-1c orchestrates metabolic remodeling of white adipose tissue by caloric restriction
    Authors: N Fujii, T Narita, N Okita, M Kobayashi, Y Furuta, Y Chujo, M Sakai, A Yamada, K Takeda, T Konishi, Y Sudo, I Shimokawa, Y Higami
    Aging Cell, 2017-03-03;0(0):.
    Species: Mouse
    Sample Types: Plasma
  102. Weight Perturbation Alters Leptin Signal Transduction in a Region-Specific Manner throughout the Brain
    Authors: MV Morabito, Y Ravussin, BR Mueller, AA Skowronski, K Watanabe, KS Foo, SX Lee, A Lehmann, S Hjorth, LM Zeltser, CA LeDuc, RL Leibel
    PLoS ONE, 2017-01-20;12(1):e0168226.
    Species: Mouse
    Sample Types: Serum
  103. Anti-Inflammatory Effects of Rosiglitazone in Obesity-Impaired Wound Healing Depend on Adipocyte Differentiation
    PLoS ONE, 2016-12-19;11(12):e0168562.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  104. Deficiency in prohormone convertase PC1 impairs prohormone processing in Prader-Willi syndrome
    Authors: Lisa C Burnett
    J. Clin. Invest, 2016-12-12;0(0):.
    Species: Mouse
    Sample Types: Plasma
  105. Traditional medicine, Sobokchukeo?Tang, modulates the inflammatory response in adipocytes and macrophages
    Mol Med Rep, 2016-12-07;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
  106. Differential body weight, blood pressure and placental inflammatory responses to normal versus high-fat diet in melanocortin-4 receptor-deficient pregnant rats
    Authors: FT Spradley, AC Palei, JP Granger
    J. Hypertens, 2016-10-01;34(10):1998-2007.
    Species: Rat
    Sample Types: Plasma
  107. Reprogramming the body weight set point by a reciprocal interaction of hypothalamic leptin sensitivity and Pomc gene expression reverts extreme obesity
    Mol Metab, 2016-08-05;5(10):869-81.
    Species: Mouse
    Sample Types: Plasma
  108. Korean Curcuma longa L. induces lipolysis and regulates leptin in adipocyte cells and rats
    Nutr Res Pract, 2016-07-29;10(5):487-493.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  109. Monocyte chemotactic protein-1 deficiency reduces spontaneous metastasis of Lewis lung carcinoma in mice fed a high-fat diet
    Oncotarget, 2016-04-26;7(17):24792-9.
    Species: Mouse
    Sample Types: Plasma
  110. Is Western Diet-Induced Nonalcoholic Steatohepatitis in Ldlr-/- Mice Reversible?
    Authors: Lytle K, Jump D
    PLoS ONE, 2016-01-13;11(1):e0146942.
    Species: Mouse
    Sample Types: Plasma
  111. Modulation of the leptin receptor mediates tumor growth and migration of pancreatic cancer cells.
    Authors: Mendonsa A, Chalfant M, Gorden L, VanSaun M
    PLoS ONE, 2015-04-28;10(4):e0126686.
    Species: Mouse
    Sample Types: Plasma
  112. Leptin ameliorates ischemic necrosis of the femoral head in rats with obesity induced by a high-fat diet.
    Authors: Zhou L, Jang K, Moon Y, Wagle S, Kim K, Lee K, Park B, Kim J
    Sci Rep, 2015-03-23;5(0):9397.
    Species: Rat
    Sample Types: Plasma
  113. Dietary restriction protects against experimental cerebral malaria via leptin modulation and T-cell mTORC1 suppression.
    Authors: Mejia P, Trevino-Villarreal J, Hine C, Harputlugil E, Lang S, Calay E, Rogers R, Wirth D, Duraisingh M, Mitchell J
    Nat Commun, 2015-01-30;6(0):6050.
    Species: Mouse
    Sample Types: Serum
  114. A spontaneous deletion within the desmoglein 3 extracellular domain of mice results in hypomorphic protein expression, immunodeficiency, and a wasting disease phenotype.
    Authors: Kountikov E, Poe J, Maclver N, Rathmell J, Tedder T
    Am J Pathol, 2014-12-24;185(3):617-30.
    Species: Mouse
    Sample Types: Serum
  115. Butter naturally enriched in cis-9, trans-11 CLA prevents hyperinsulinemia and increases both serum HDL cholesterol and triacylglycerol levels in rats.
    Authors: de Almeida M, Luquetti S, Sabarense C, do Amaral Correa J, dos Reis L, Santos da Conceicao E, Lisboa P, de Moura E, Gameiro J, da Gama M, Lopes F, Garcia R
    Lipids Health Dis, 2014-12-22;13(0):200.
    Species: Rat
    Sample Types: Serum
  116. Protopanaxatriol, a novel PPARgamma antagonist from Panax ginseng, alleviates steatosis in mice.
    Authors: Zhang Y, Yu L, Cai W, Fan S, Feng L, Ji G, Huang C
    Sci Rep, 2014-12-09;4(0):7375.
    Species: Mouse
    Sample Types: Serum
  117. Ghrelin induces leptin resistance by activation of suppressor of cytokine signaling 3 expression in male rats: implications in satiety regulation.
    Authors: Heldsinger A, Grabauskas G, Wu X, Zhou S, Lu Y, Song I, Owyang C
    Endocrinology, 2014-07-25;155(10):3956-69.
    Species: Rat
    Sample Types: Plasma
  118. A leptin-mediated central mechanism in analgesia-enhanced opioid reward in rats.
    Authors: Lim G, Kim H, McCabe M, Chou C, Wang S, Chen L, Marota J, Blood A, Breiter H, Mao J
    J Neurosci, 2014-07-16;34(29):9779-88.
    Species: Rat
    Sample Types: Serum
  119. Transgenic mice overexpressing amyloid precursor protein exhibit early metabolic deficits and a pathologically low leptin state associated with hypothalamic dysfunction in arcuate neuropeptide Y neurons.
    Authors: Ishii M, Wang G, Racchumi G, Dyke J, Iadecola C
    J Neurosci, 2014-07-02;34(27):9096-106.
    Species: Mouse
    Sample Types: Plasma
  120. Rescue of cardiac leptin receptors in db/db mice prevents myocardial triglyceride accumulation.
    Authors: Hall M, Maready M, Hall J, Stec D
    Am J Physiol Endocrinol Metab, 2014-06-17;307(3):E316-25.
    Species: Mouse
    Sample Types: Plasma
  121. PKClambda haploinsufficiency prevents diabetes by a mechanism involving alterations in hepatic enzymes.
    Authors: Sajan M, Ivey R, Lee M, Mastorides S, Jurczak M, Samuels V, Shulman G, Braun U, Leitges M, Farese R
    Mol Endocrinol, 2014-05-30;28(7):1097-107.
    Species: Mouse
    Sample Types: Serum
  122. Lipid profiling and transcriptomic analysis reveals a functional interplay between estradiol and growth hormone in liver.
    Authors: Fernandez-Perez L, Santana-Farre R, de Mirecki-Garrido M, Garcia I, Guerra B, Mateo-Diaz C, Iglesias-Gato D, Diaz-Chico J, Flores-Morales A, Diaz M
    PLoS ONE, 2014-05-09;9(5):e96305.
    Species: Rat
    Sample Types: Serum
  123. Beneficial metabolic effects of rapamycin are associated with enhanced regulatory cells in diet-induced obese mice.
    Authors: Makki K, Taront S, Molendi-Coste O, Bouchaert E, Neve B, Eury E, Lobbens S, Labalette M, Duez H, Staels B, Dombrowicz D, Froguel P, Wolowczuk I
    PLoS ONE, 2014-04-07;9(4):e92684.
    Species: Mouse
    Sample Types: Serum
  124. Moderate calorie restriction during gestation programs offspring for lower BAT thermogenic capacity driven by thyroid and sympathetic signaling.
    Authors: Palou M, Priego T, Romero M, Szostaczuk N, Konieczna J, Cabrer C, Remesar X, Palou A, Pico C
    Int J Obes (Lond), 2014-04-03;39(2):339-45.
    Species: Rat
    Sample Types: Plasma
  125. Temporal changes in nutritional state affect hypothalamic POMC peptide levels independently of leptin in adult male mice.
    Authors: Mercer A, Stuart R, Attard C, Otero-Corchon V, Nillni E, Low M
    Am J Physiol Endocrinol Metab, 2014-02-11;306(8):E904-15.
    Species: Mouse
    Sample Types: Plasma
  126. Effect of intermittent cold exposure on brown fat activation, obesity, and energy homeostasis in mice.
    Authors: Ravussin Y, Xiao C, Gavrilova O, Reitman M
    PLoS ONE, 2014-01-17;9(1):e85876.
    Species: Mouse
    Sample Types: Serum
  127. Hypermethylation of Sp1 binding site suppresses hypothalamic POMC in neonates and may contribute to metabolic disorders in adults: impact of maternal dietary CLAs.
    Authors: Zhang, Xiaomei, Yang, Ran, Jia, Yan, Cai, Demin, Zhou, Bo, Qu, Xiaoli, Han, Huihua, Xu, Liang, Wang, Linfeng, Yao, Yanan, Yang, Guoqing
    Diabetes, 2013-12-30;63(5):1475-87.
    Species: Mouse
    Sample Types: Plasma
  128. Blockade of the cerebral aqueduct in rats provides evidence of antagonistic leptin responses in the forebrain and hindbrain.
    Authors: Vaill M, Desai B, Harris R
    Am J Physiol Endocrinol Metab, 2013-12-17;306(4):E414-23.
    Species: Rat
    Sample Types: CSF
  129. Exercise protects against diet-induced insulin resistance through downregulation of protein kinase Cbeta in mice.
    Authors: Rao X, Zhong J, Xu X, Jordan B, Maurya S, Braunstein Z, Wang T, Huang W, Aggarwal S, Periasamy M, Rajagopalan S, Mehta K, Sun Q
    PLoS ONE, 2013-12-09;8(12):e81364.
    Species: Mouse
    Sample Types: Plasma
  130. Oral leptin treatment in suckling rats ameliorates detrimental effects in hypothalamic structure and function caused by maternal caloric restriction during gestation.
    Authors: Konieczna J, Garcia A, Sanchez J, Palou M, Palou A, Pico C
    PLoS ONE, 2013-11-28;8(11):e81906.
    Species: Rat
    Sample Types: Plasma
  131. Leptin metabolically licenses T cells for activation to link nutrition and immunity.
    Authors: Saucillo, Donte C, Gerriets, Valerie, Sheng, John, Rathmell, Jeffrey, Maciver, Nancie J
    J Immunol, 2013-11-22;192(1):136-44.
    Species: Mouse
    Sample Types: Serum
  132. T-cell costimulation protects obesity-induced adipose inflammation and insulin resistance.
    Authors: Zhong, Jixin, Rao, Xiaoquan, Braunstein, Zachary, Taylor, Anne, Narula, Vimal, Hazey, Jeffrey, Mikami, Dean, Needleman, Bradley, Rutsky, Jessica, Sun, Qinghua, Deiuliis, Jeffrey, Satoskar, Abhay R, Rajagopalan, Sanjay
    Diabetes, 2013-11-12;63(4):1289-302.
    Species: Mouse
    Sample Types: Serum
  133. Obesity induced a leptin-Notch signaling axis in breast cancer.
    Authors: Battle M, Gillespie C, Quarshie A, Lanier V, Harmon T, Wilson K, Torroella-Kouri M, Gonzalez-Perez R
    Int J Cancer, 2013-10-08;134(7):1605-16.
    Species: Mouse
    Sample Types: Plasma
  134. Euglycemic hyperinsulinemia increases blood pressure in pregnant rats independent of placental antiangiogenic and inflammatory factors.
    Authors: Palei A, Spradley F, Granger J
    Am J Hypertens, 2013-08-16;26(12):1445-51.
    Species: Rat
    Sample Types: Serum
  135. HDL and Glut1 inhibition reverse a hypermetabolic state in mouse models of myeloproliferative disorders.
    Authors: Gautier E, Westerterp M, Bhagwat N, Cremers S, Shih A, Abdel-Wahab O, Lutjohann D, Randolph G, Levine R, Tall A, Yvan-Charvet L
    J Exp Med, 2013-01-14;210(2):339-53.
    Species: Mouse
    Sample Types: Plasma
  136. Enhanced leptin sensitivity, reduced adiposity, and improved glucose homeostasis in mice lacking exchange protein directly activated by cyclic AMP isoform 1.
    Authors: Yan J, Mei F, Cheng H, Lao D, Hu Y, Wei J, Patrikeev I, Hao D, Stutz S, Dineley K, Motamedi M, Hommel J, Cunningham K, Chen J, Cheng X
    Mol Cell Biol, 2012-12-21;33(5):918-26.
    Species: Mouse
    Sample Types: Plasma
  137. Obesity in mice with adipocyte-specific deletion of clock component Arntl.
    Authors: Paschos, Georgios, Ibrahim, Salam, Song, Wen-Lian, Kunieda, Takeshig, Grant, Gregory, Reyes, Teresa M, Bradfield, Christop, Vaughan, Cheryl H, Eiden, Michael, Masoodi, Mojgan, Griffin, Julian L, Wang, Fenfen, Lawson, John A, Fitzgerald, Garret A
    Nat Med, 2012-11-11;18(12):1768-77.
    Species: Mouse
    Sample Types: Plasma
  138. Obesity and IL-6 interact in modulating the response to endotoxemia in mice.
    Cytokine, 2012-09-23;61(1):71-7.
    Species: Mouse
    Sample Types: Plasma
  139. Tangeretin stimulates glucose uptake via regulation of AMPK signaling pathways in C2C12 myotubes and improves glucose tolerance in high-fat diet-induced obese mice.
    Mol. Cell. Endocrinol., 2012-03-28;358(1):127-34.
    Species: Mouse
    Sample Types: Serum
  140. HCV core-induced nonobese hepatic steatosis is associated with hypoadiponectinemia and is ameliorated by adiponectin administration.
    Authors: Chang ML, Yeh HC, Tsou YK
    Obesity (Silver Spring), 2012-02-23;20(7):1474-80.
    Species: Mouse
    Sample Types: Serum
  141. Disruption of the chemokine-like receptor-1 (CMKLR1) gene is associated with reduced adiposity and glucose intolerance.
    Authors: Ernst MC, Haidl ID, Zúñiga LA, Dranse HJ, Rourke JL, Zabel BA, Butcher EC, Sinal CJ
    Endocrinology, 2011-12-20;153(2):672-82.
    Species: Mouse
    Sample Types: Serum
  142. Castration-induced changes in mouse epididymal white adipose tissue.
    Authors: Floryk D, Kurosaka S, Tanimoto R, Yang G, Goltsov A, Park S, Thompson TC
    Mol. Cell. Endocrinol., 2011-07-12;345(1):58-67.
    Species: Mouse
    Sample Types: Serum
  143. Caloric restriction reduces growth of mammary tumors and metastases.
    Authors: De Lorenzo M, Baljinnyam E, Vatner D, Abarzua P, Vatner S, Rabson A
    Carcinogenesis, 2011-06-10;32(9):1381-7.
    Species: Mouse
    Sample Types: Serum
  144. Fasting induces an anti-inflammatory effect on the neuroimmune system which a high-fat diet prevents.
    Authors: Lavin DN, Joesting JJ, Chiu GS, Moon ML, Meng J, Dilger RN, Freund GG
    Obesity (Silver Spring), 2011-04-28;19(8):1586-94.
    Species: Mouse
    Sample Types: Serum
  145. Perinatal lack of maternal IL-6 promotes increased adiposity during adulthood in mice.
    Authors: Lager S, Asterholm IW, Schele E, Jansson N, Nilsson S, Jansson JO, Lonn M, Holmang A
    Endocrinology, 2011-02-01;152(4):1336-46.
    Species: Mouse
    Sample Types: Milk
  146. Physiological roles of group X-secreted phospholipase A2 in reproduction, gastrointestinal phospholipid digestion, and neuronal function.
    Authors: Sato H, Isogai Y, Masuda S
    J. Biol. Chem., 2011-01-25;286(13):11632-48.
    Species: Mouse
    Sample Types: Serum
  147. Deletion of Nhlh2 results in a defective torpor response and reduced Beta adrenergic receptor expression in adipose tissue.
    Authors: Wankhade UD, Vella KR, Fox DL
    PLoS ONE, 2010-08-23;5(8):e12324.
    Species: Mouse
    Sample Types: Serum
  148. Group X secretory phospholipase A2 negatively regulates adipogenesis in murine models.
    Authors: Li X, Shridas P, Forrest K, Bailey W, Webb NR
    FASEB J., 2010-06-28;24(11):4313-24.
    Species: Mouse
    Sample Types: Plasma
  149. Leptin exacerbates sepsis-mediated morbidity and mortality.
    Authors: Shapiro NI, Khankin EV, van Meurs M
    J. Immunol., 2010-06-02;185(1):517-24.
    Species: Mouse
    Sample Types: Plasma
  150. Differential effects of high MUFA with high or low P/S ratio (polyunsaturated to saturated fatty acids) on improving hepatic lipolytic enzymes and mediating PPARgamma related with lipoprotein lipase and hormone-sensitive lipase of white adipose tissue in diet-induced obese hamster.
    Authors: Liao FH, Liou TH, Chiu WC, Shieh MJ, Chien YW
    Int J Obes (Lond), 2010-05-11;34(11):1608-17.
    Species: Hamster
    Sample Types: Plasma
  151. eNOS plays a major role in adiponectin synthesis in adipocytes.
    Authors: Koh EH, Kim M, Ranjan KC, Kim HS, Park HS, Oh KS, Park IS, Lee WJ, Kim MS, Park JY, Youn JH, Lee KU
    Am. J. Physiol. Endocrinol. Metab., 2010-02-02;298(4):E846-53.
    Species: Mouse
    Sample Types: Plasma
  152. Neutralization of osteopontin inhibits obesity-induced inflammation and insulin resistance.
    Authors: Kiefer FW, Zeyda M, Gollinger K, Pfau B, Neuhofer A, Weichhart T, Saemann MD, Geyeregger R, Schlederer M, Kenner L, Stulnig TM
    Diabetes, 2010-01-27;59(4):935-46.
    Species: Mouse
    Sample Types: Plasma
  153. Moderate caloric restriction in lactating rats protects offspring against obesity and insulin resistance in later life.
    Authors: Palou M, Priego T, Sanchez J, Torrens JM, Palou A, Pico C
    Endocrinology, 2010-01-12;151(3):1030-41.
    Species: Rat
    Sample Types: Milk
  154. Varying susceptibility of pulmonary cytokine production to lipopolysaccharide in mice.
    Authors: Alm AS, Li K, Yang D, Andersson R, Lu Y, Wang X
    Cytokine, 2009-12-29;49(3):256-63.
    Species: Mouse
    Sample Types: BALF
  155. Development of obesity in the Otsuka Long-Evans Tokushima Fatty rat.
    Authors: Schroeder M, Zagoory-Sharon O, Shbiro L, Marco A, Hyun J, Moran TH, Bi S, Weller A
    Am. J. Physiol. Regul. Integr. Comp. Physiol., 2009-09-30;297(6):R1749-60.
    Species: Rat
    Sample Types: Plasma
  156. Enhanced production of IL-17A during zymosan-induced peritonitis in obese mice.
    Authors: Pini M, Fantuzzi G
    J. Leukoc. Biol., 2009-09-10;87(1):51-8.
    Species: Mouse
    Sample Types: Peritoneal Lavage Fluid
  157. Efficient method for obtaining Lep(ob)/Lep(ob)-derived animal models using adipose tissue transplantations.
    Authors: Barros CC, Almeida SS, Mori MA, Valero VB, Haro AS, Batista EC, Rosa TS, Bacurau RF, Wurtele M, Araujo RC
    Int J Obes (Lond), 2009-06-16;33(8):938-44.
    Species: Mouse
    Sample Types: Serum
  158. Early handling increases susceptibility to experimental autoimmune encephalomyelitis (EAE) in C57BL/6 male mice.
    Authors: Columba-Cabezas S, Iaffaldano G, Chiarotti F, Alleva E, Cirulli F
    J. Neuroimmunol., 2009-06-02;212(1):10-6.
    Species: Mouse
    Sample Types: Serum
  159. Spinal leptin contributes to the pathogenesis of neuropathic pain in rodents.
    Authors: Lim G, Wang S, Zhang Y, Tian Y, Mao J
    J. Clin. Invest., 2009-01-12;119(2):295-304.
    Species: Rat
    Sample Types: Plasma
  160. Stearoyl-CoA desaturase 1 deficiency protects mice from immune-mediated liver injury.
    Authors: Feng D, Wang Y, Mei Y, Xu Y, Xu H, Lu Y, Luo Q, Zhou S, Kong X, Xu L
    Lab. Invest., 2008-11-10;89(2):222-30.
    Species: Mouse
    Sample Types: Plasma
  161. Hepatic CB1 receptor is required for development of diet-induced steatosis, dyslipidemia, and insulin and leptin resistance in mice.
    Authors: Osei-Hyiaman D, Liu J, Zhou L, Godlewski G, Harvey-White J, Jeong WI, Batkai S, Marsicano G, Lutz B, Buettner C, Kunos G
    J. Clin. Invest., 2008-09-01;118(9):3160-9.
    Species: Mouse
    Sample Types: Plasma
  162. Adaptation to lactation in OLETF rats lacking CCK-1 receptors: body weight, fat tissues, leptin and oxytocin.
    Authors: Zagoory-Sharon O, Schroeder M, Levine A, Moran TH, Weller A
    Int J Obes (Lond), 2008-05-06;32(8):1211-21.
    Species: Rat
    Sample Types: Plasma
  163. Doubly truncated FosB isoform (Delta2DeltaFosB) induces osteosclerosis in transgenic mice and modulates expression and phosphorylation of Smads in osteoblasts independent of intrinsic AP-1 activity.
    Authors: Sabatakos G, Rowe GC, Kveiborg M, Wu M, Neff L, Chiusaroli R, Philbrick WM, Baron R
    J. Bone Miner. Res., 2008-05-01;23(5):584-95.
    Species: Mouse
    Sample Types: Serum
  164. Role and regulation of adipokines during zymosan-induced peritoneal inflammation in mice.
    Authors: Pini M, Gove ME, Sennello JA, van Baal JW, Chan L, Fantuzzi G
    Endocrinology, 2008-05-01;149(8):4080-5.
    Species: Mouse
    Sample Types: Serum
  165. Identification of ALOX5 as a gene regulating adiposity and pancreatic function.
    Authors: Mehrabian M, Schulthess FT, Nebohacova M, Castellani LW, Zhou Z, Hartiala J, Oberholzer J, Lusis AJ, Maedler K, Allayee H
    Diabetologia, 2008-04-18;51(6):978-88.
    Species: Mouse
    Sample Types: Plasma
  166. Octylphenol stimulates resistin gene expression in 3T3-L1 adipocytes via the estrogen receptor and extracellular signal-regulated kinase pathways.
    Authors: Lee MJ, Lin H, Liu CW, Wu MH, Liao WJ, Chang HH, Ku HC, Chien YS, Ding WH, Kao YH
    Am. J. Physiol., Cell Physiol., 2008-04-16;294(6):C1542-51.
    Species: Mouse
    Sample Types: Serum
  167. Novel black soy peptides with antiobesity effects: activation of leptin-like signaling and AMP-activated protein kinase.
    Authors: Jang EH, Moon JS, Ko JH, Ahn CW, Lee HH, Shin JK, Park CS, Kang JH
    Int J Obes (Lond), 2008-04-15;32(7):1161-70.
    Species: Mouse
    Sample Types: Plasma
  168. Signal transducer and activator of transcription-3 is required in hypothalamic agouti-related protein/neuropeptide Y neurons for normal energy homeostasis.
    Authors: Gong L, Yao F, Hockman K, Heng HH, Morton GJ, Takeda K, Akira S, Low MJ, Rubinstein M, MacKenzie RG
    Endocrinology, 2008-04-10;149(7):3346-54.
    Species: Mouse
    Sample Types: Plasma
  169. FXR-deficiency confers increased susceptibility to torpor.
    Authors: Cariou B, Bouchaert E, Abdelkarim M, Dumont J, Caron S, Fruchart JC, Burcelin R, Kuipers F, Staels B
    FEBS Lett., 2007-10-12;581(27):5191-8.
    Species: Mouse
    Sample Types: Plasma
  170. High circulating leptin receptors with normal leptin sensitivity in liver-specific insulin receptor knock-out (LIRKO) mice.
    Authors: Cohen SE, Kokkotou E, Biddinger SB, Kondo T, Gebhardt R, Kratzsch J, Mantzoros CS, Kahn CR
    J. Biol. Chem., 2007-06-07;282(32):23672-8.
    Species: Mouse
    Sample Types: Serum
  171. Leptin induces elongation of cardiac myocytes and causes eccentric left ventricular dilatation with compensation.
    Authors: Abe Y, Ono K, Kawamura T, Wada H, Kita T, Shimatsu A, Hasegawa K
    Am. J. Physiol. Heart Circ. Physiol., 2007-01-12;292(5):H2387-96.
    Species: Mouse
    Sample Types: Plasma
  172. Leptin resistance protects mice from hyperoxia-induced acute lung injury.
    Authors: Bellmeyer A, Martino JM, Chandel NS, Scott Budinger GR, Dean DA, Mutlu GM
    Am. J. Respir. Crit. Care Med., 2006-12-21;175(6):587-94.
    Species: Mouse
    Sample Types: BALF
  173. Impaired adipose tissue development in mice with inactivation of placental growth factor function.
    Authors: Lijnen HR, Christiaens V, Scroyen I, Voros G, Tjwa M, Carmeliet P, Collen D
    Diabetes, 2006-10-01;55(10):2698-704.
    Species: Mouse
    Sample Types: Tissue Homogenates
  174. Integrating genetic and network analysis to characterize genes related to mouse weight.
    Authors: Ghazalpour A, Doss S, Zhang B, Wang S, Plaisier C, Castellanos R, Brozell A, Schadt EE, Drake TA, Lusis AJ, Horvath S
    PLoS Genet., 2006-07-05;2(8):e130.
    Species: Mouse
    Sample Types: Plasma
  175. Long-term blockade of angiotensin AT1 receptors increases survival of obese Zucker rats.
    Authors: O&amp;apos;Connor SE
    Eur. J. Pharmacol., 2006-03-06;534(1):271-9.
    Species: Mouse
    Sample Types: Plasma
  176. Metformin restores leptin sensitivity in high-fat-fed obese rats with leptin resistance.
    Authors: Kim YW, Kim JY, Park YH, Park SY, Won KC, Choi KH, Huh JY, Moon KH
    Diabetes, 2006-03-01;55(3):716-24.
    Species: Rat
    Sample Types: CSF
  177. Diurnal rhythms of leptin and ghrelin in the systemic circulation and in the gastric mucosa are related to food intake in rats.
    Authors: Sanchez J, Oliver P, Pico C, Palou A
    Pflugers Arch., 2004-04-24;448(5):500-6.
    Species: Rat
    Sample Types: Serum
  178. Role of leptin deficiency in early acute renal failure during endotoxemia in ob/ob mice.
    Authors: Wang W, Poole B, Mitra A, Falk S, Fantuzzi G, Lucia S, Schrier R
    J. Am. Soc. Nephrol., 2004-03-01;15(3):645-9.
    Species: Mouse
    Sample Types: Serum
  179. The increased bone mass in deltaFosB transgenic mice is independent of circulating leptin levels.
    Authors: Kveiborg M, Chiusaroli R, Sims NA, Wu M, Sabatakos G, Horne WC, Baron R
    Endocrinology, 2002-11-01;143(11):4304-9.
    Species: Mouse
    Sample Types: Serum
  180. Leptin accelerates autoimmune diabetes in female NOD mice.
    Authors: Matarese G, Sanna V, Lechler RI, Sarvetnick N, Fontana S, Zappacosta S, La Cava A
    Diabetes, 2002-05-01;51(5):1356-61.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  181. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity.
    Authors: Yamauchi, T, Kamon, J, Waki, H, Terauchi, Y, Kubota, N, Hara, K, Mori, Y, Ide, T, Murakami, K, Tsuboyama-Kasaoka, N, Ezaki, O, Akanuma, Y, Gavrilova, O, Vinson, C, Reitman, M L, Kagechika, H, Shudo, K, Yoda, M, Nakano, Y, Tobe, K, Nagai, R, Kimura, S, Tomita, M, Froguel, P, Kadowaki, T
    Nat Med, 2001-08-01;7(8):941-6.
    Species: Mouse
    Sample Types: Plasma

FAQs

  1. Why is the acid activation procedure required for pregnant mouse serum samples from second trimester through post-partum day 1 in the Mouse/Rat Leptin Quantikine® ELISA assay?

    • Mouse Leptin R intereferes in the MOB00 assay at high concentration >2000 pg/mL, and studies have shown that there is a massive increase in the level of criculating Leptin Receptor (OB-R) during later stage of pregnancy. Acid activation helps to dissociate the interaction between Leptin and its high affinity recceptor OB-R thus minimizing possible interference in the Leptin assay. Note that activation is not required for samples obtained from non-pregnant mice. Ref. J. Biol. Chem (1997) 272(48):30546-51.

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Mouse/Rat Leptin Quantikine ELISA Kit
By Leslie Priddy on 04/03/2018
Sample Tested: Serum
Mouse/Rat Leptin Quantikine ELISA Kit
By Anonymous on 06/05/2017
Sample Tested: 7TD1 mouse hybridoma cell line
Mouse/Rat Leptin Quantikine ELISA Kit
By Boubacar Barry on 06/01/2017
Sample Tested: Mouse/Rat Leptin Elisa Kit
Mouse/Rat Leptin Quantikine ELISA Kit
By Anonymous on 04/21/2017
Sample Tested: Purified mouse IL-1beta protein