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Mpro 61

Catalog #: 7695 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7695/5
Mpro 61 | CAS No. 2679814-93-6 | 3C and 3CL Protease Inhibitors
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Description: Potent non-covalent inhibitor of SARS-CoV-2 main protease

Chemical Name: 5-[5-[3-Chloro-5-[(2-chlorophenyl)methoxy]-4-fluorophenyl]-6-oxo[1(6H),3'-bipyridin]-3-yl]-1-methyl-2,4(1H,3H)-pyrimidinedione

Purity: ≥95%

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Biological Activity

Mpro 61 is a potent non-covalent inhibitor of SARS-CoV-2 main protease (IC50 = 44 nM, EC50 = 0.175 μM in the replicon assay and EC50 = 0.08 μM in the infectious SARS-CoV-2 assay); it is cell permable and exhibits no apparent cytotoxicity.

Technical Data

M.Wt:
565.38
Formula:
C28H19Cl2FN4O4
Solubility:
Soluble to 20 mM in DMSO
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
2679814-93-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from Yale University. U.S. patent application number 63/135,062.

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