MS 275

Biological Activity

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. A synthetic inhibitor of histone deacetylase, MS-27-275, with marked in vivo antitumor activity against human tumors.
   Saito et al.
   Proc.Natl.Acad.Sci., 1999;96:4592
2. Distinct pharmacological properties of second generation HDAC inhibitors with the benzamide or hydroxamate head group.
   Beckers et al.
   Int.J.Cancer, 2007;121:1138
3. MS-275 inhibits aroclor 1254-induced SH-SY5Y neuronal cell toxicity by preventing the formation of the HDAC3/REST complex on the synapsin-1 promoter.
   Formisano et al.
   J.Pharmacol.Exp.Ther., 2015;352:236
4. Functional activation of the estrogen receptor-α and aromatase by the HDAC inhibitor entinostat sensitizes ER-negative tumors to letr.
   Sabnis et al.
   Cancer Res., 2011;71:1893

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