NAI-N3
Discontinued Product
7003 has been discontinued.
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Description: Reagent for RNA icSHAPE experiments in vivo
Chemical Name: [2-(Azidomethyl)-3-pyridinyl]-1H-imidazol-1-ylmethanone
Biological Activity
NAI-N3 is a probe for icSHAPE (in vivo click selective 2'-hydroxyl acylation and profiling experiment). Acylates the 2'-OH in ssRNA. Enables RNA structure profiling in vivo and ex vivo for all four bases. NAI-N3 can be used for site-specific RNA acylation using the RAIL (RNA Acylation at Induced Loops) method or in Apta-Seq to discover new aptamers in selected pools.Technical Data
M.Wt:
228.22
Formula:
C10H8N6O
Solubility:
Soluble in DMSO (supplied pre-dissolved in DMSO, 1M)
Storage:
Store at -20°C
CAS No:
1612756-29-2
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
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Background References
-
Comparison of SHAPE reagents for mapping RNA structures inside living cells.
Lee et al.
RNA, 2017;23:169 -
Structural imprints in vivo decode RNA regulatory mechanisms.
Spitale et al.
Nature, 2015;519:486 -
Site-selective RNA functionalization via DNA-induced structure.
Xiao et al.
J.Am.Chem.Soc., 2020;142:16357 -
Multiplex aptamer discovery through Apta-Seq and its application to ATP aptamers derived from human-genomic SELEX.
Abdelsayed et al.
ACS Chem.Biol., 2017;12:2149
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