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NFPS

Catalog #: 2789
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
2789/10
2789/50
NFPS | CAS No. 405225-21-0 | Glycine Transporter Inhibitors
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Description: Selective non-transportable GlyT1 inhibitor
Alternative Names: (±)-NFPS

Chemical Name: N-[3-([1,1-Biphenyl]-4-yloxy)-3-(4-fluorophenyl)propyl]-N-methylglycine

Purity: ≥98%

Product Details
Citations (2)
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Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

NFPS is a selective, non-transportable inhibitor of GlyT1 which displays no activity at GABA or glutamate receptors (IC50 values are 2.8, 9.8 and 56000 nM for hGlyT1, rGlyT1 and rGlyT2 respectively). Enhances the amplitude of the NMDA component of glutamatergic EPSCs.

R-enantiomer also available.

Technical Data

M.Wt:
393.45
Formula:
C24H24FNO3
Solubility:
Soluble to 10 mM in DMSO and to 5 mM in ethanol with gentle warming
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
405225-21-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Other Product-Specific Information:

Background References

  1. Pharmacology and expression analysis of glycine transporter GlyT1 with [3H]-(N-[3-(4'-fluorophenyl)-3-(4'phenylphenoxy)propyl])sarcosine.
    Mallorga et al.
    Neuropharmacology, 2003;45:585
  2. Modulation of N-MthD.-aspartate receptor function by glycine transport.
    Bergeron et al.
    Proc.Natl.Acad.Sci.USA, 1998;95:15730
  3. The glycine transporter-1 inhibitors NFPS and Org 24461: a pharmacological study.
    Harsing Jr. et al.
    Pharmacol.Biochem.Behav., 2003;74:881

Product Datasheets

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Citations for NFPS

The citations listed below are publications that use Tocris products. Selected citations for NFPS include:

2 Citations: Showing 1 - 2

  1. Colocalization of neurotransmitter transporters on the plasma membrane of the same nerve terminal may reflect cotransmission.
    Authors: Romei Et al.
    Brain Research Bulletin  2016;127:100
  2. Probing the modulation of acute ethanol intoxication by pharmacological manipulation of the NMDAR glycine co-agonist site.
    Authors: DeBrouse Et al.
    Alcohol Clin Exp Res  2013;37:223

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