Nitrendipine
Discontinued Product
Chemical Name: 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine dicarboxylic acid ethyl methyl ester
Purity: ≥99%
Biological Activity
Nitrendipine is a L-type calcium channel blocker. Induces autophagy.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Mutant LRRK2 elicits calcium imbalance and depletion of dendritic mitochondria in neurons.
Am J Pathol, 2013;182(2):474-84. -
High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
Chemical modulators of autophagy as biological probes and potential therapeutics.
Fleming et al.
Nat.Chem.Biol., 2011;7:9 -
Characterization of a voltage-dependent L-type calcium channel from rabbit and turtle brain.
Costa et al.
Neurochem.Res., 1996;21:537 -
L-type calcium channel block by highly hydrophilic dihydropyridines in single ventricular cells of guinea-pig hearts.
Watanabe et al.
J.Mol.Cell.Cardiol., 1995;27:1271
Product Datasheets
Citations for Nitrendipine
The citations listed below are publications that use Tocris products. Selected citations for Nitrendipine include:
3 Citations: Showing 1 - 3
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Erk1/2 inhibit synaptic vesicle exocytosis through L-type calcium channels.
Authors: Subramanian and Morozov
J Neurosci 2011;31:4755
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Regulation of protease-activated receptor-1 by vasodilatory prostaglandins via NFAT.
Authors: Rosenkranz Et al.
Cardiovasc Res 2009;83:778
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Glutamate controls growth rate and branching of DArgic axons.
Authors: Schmitz Et al.
J Neurosci 2009;29:11973
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