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NMDA

Catalog #: 0114
91 Citations 1 Review Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
0114/50
0114/500
NMDA | CAS No. 6384-92-5 | NMDA Receptor Agonists
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Description: Selective NMDA agonist

Chemical Name: N-Methyl-D-aspartic acid

Purity: ≥99%

Product Details
Citations (91)
Supplemental Products
Reviews (1)
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

NMDA is a prototypic NMDA receptor agonist.

Caged version also available (Cat. No 2224).

Technical Data

M.Wt:
147.13
Formula:
C5H9NO4
Solubility:
Soluble to 100 mM in water
Purity:
≥99%
Storage:
Store at RT
CAS No:
6384-92-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Neuromuscular NMDA Receptors Modulate Developmental Synapse Elimination
    KE Personius, BS Slusher, SB Udin
    J. Neurosci, 2016;36(34):8783-9.
  2. Sapap3 deletion anomalously activates short-term endocannabinoid-mediated synaptic plasticity.
    Chen, Meng, Wan, Yehong, Ade, Kristen, Ting, Jonathan, Feng, Guoping, Calakos, Nicole
    J Neurosci, 2011;31(26):9563-73.
  3. Potentiation of NMDA receptor-dependent cell responses by extracellular high mobility group box 1 protein.
    Pedrazzi, Marco, Averna, Monica, Sparatore, Bianca, Patrone, Mauro, Salamino, Franca, Marcoli, Manuela, Maura, Guido, Cervetto, Chiara, Frattaroli, Daniela, Pontremoli, Sandro, Melloni, Edon
    PLoS ONE, 2012;7(8):e44518.
  4. Olanzapine: preclinical and clinical profiles of a novel antipsychotic agent.
    Tollefson and Taylor
    CNS Drug Reviews, 2000;6:303
  5. Excitatory amino acids.
    Watkins
    Kainic acid as a Tool in Neurobiology. Edited by E, 1978;:37
  6. Excitatory amino acid transmitters.
    Watkins and Evans
    Annu.Rev.Pharmacol.Toxicol., 1981;21:165

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Citations for NMDA

The citations listed below are publications that use Tocris products. Selected citations for NMDA include:

91 Citations: Showing 1 - 10

  1. Maladaptive Downregulation of Autonomous Subthalamic Nucleus Activity following the Loss of Midbrain Dopamine Neurons.
    Authors: McIver Et al.
    Cell Rep  2019;28:992
  2. Oligodendrocyte Progenitor Cells Become Regionally Diverse and Heterogeneous with Age.
    Authors: Spitzer Et al.
    Neuron  2019;101:459
  3. The axonal motor neuropathy-related HINT1 protein is a zinc- and calmodulin-regulated cysteine SUMO protease.
    Authors: Cortés-Montero Et al.
    Antioxid Redox Signal  2019;
  4. Fenfluramine diminishes NMDA receptor-mediated seizures via its mixed activity at serotonin 5HT2A and type 1 sigma receptors.
    Authors: Rodríguez-Muñoz Et al.
    Oncotarget  2018;9:23373
  5. GABAergic inhibition in dual-transmission cholinergic and GABAergic striatal interneurons is abolished in Parkinson disease.
    Authors: Lozovaya Et al.
    Nat Commun  2018;9(1):1422
  6. Neuronal Activity-Dependent Activation of Astroglial Calcineurin in Mouse Primary Hippocampal Cultures.
    Authors: Lim Et al.
    Int J Mol Sci  2018;19
  7. Cannabidiol enhances MOR antinociception, diminishes NMDA-mediated seizures and reduces stroke damage via the sigma 1 receptor.
    Authors: Rodríguez-Muñoz Et al.
    Mol Brain  2018;11:51
  8. The major neurotransmitter systems in the basolateral amygdala and the ventral tegmental areamediate morphine-induced memory consolidation impairment.
    Authors: Sharifi
    Neuroscience  2017;353:7
  9. Nitric Oxide Is Required for L-Type Ca(2+) Channel-Dependent Long-Term Potentiation in the Hippocampus.
    Authors: Pigott and Garthwaite
    Front Synaptic Neurosci  2016;8:17
  10. The calcium sensor Copine-6 regulates spine structural plasticity and learning and memory.
    Authors: Reinhard Et al.
    Nat Commun  2016;7:11613
  11. Transient Oxygen/Glucose Deprivation Causes a Delayed Loss of Mitochondria and Increases Spontaneous Calcium Signaling in Astrocytic Processes.
    Authors: O'Donnell Et al.
    J Neurosci  2016;36:7109
  12. Activation of calcineurin underlies altered trafficking of α2 subunit containing GABAA receptors during prolonged epileptiform activity.
    Authors: Eckel Et al.
    Neuropharmacology  2015;88:82
  13. Conformations of tissue plasminogen activator (tPA) orchestrate neuronal survival by a crosstalk between EGFR and NMDAR.
    Authors: Bertrand Et al.
    Cell Death Dis  2015;6:e1924
  14. Brain ischemia downregulates the neuroprotective GDNF-Ret signaling by a calpain-dependent mechanism in cultured hippocampal neurons.
    Authors: Curcio Et al.
    Cell Death Dis  2015;6:e1645
  15. The higher order auditory cortex is involved in the assignment of affective value to sensory stimuli.
    Authors: Grosso Et al.
    Nat Commun  2015;6:8886
  16. Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2.
    Authors: Bell Et al.
    Nat Commun  2015;6:7066
  17. The ON:OFF switch, σ1R-HINT1 protein, controls GPCR-NMDA receptor cross-regulation: implications in neurological disorders.
    Authors: Rodríguez-Muñoz Et al.
    Oncotarget  2015;6:35458
  18. Nitric oxide targets oligodendrocytes and promotes their morphological differentiation.
    Authors: Garthwaite Et al.
    Glia  2015;63:383
  19. Impact of subanesthetic doses of KA on AMPA-mediated responses in rats: An in vivo electrophysiological study on monoaminergic and glutamatergic neurons.
    Authors: Iskandrani Et al.
    J Psychopharmacol  2015;29:792
  20. CaMKII mediates recruitment and activation of the deubiquitinase CYLD at the postsynaptic density.
    Authors: Thein Et al.
    PLoS One  2014;9:e91312
  21. Neuritin can normalize neural deficits of Alzheimer's disease.
    Authors: An Et al.
    Cell Death Dis  2014;5:e1523
  22. KA alters cortical integration of GABAergic interneurons and induces long-term sex-dependent impairments in transgenic Gad67-GFP mice.
    Authors: Aligny Et al.
    Cell Death Dis  2014;5:e1311
  23. Presynaptic GABAergic inhibition regulated by BDNF contributes to neuropathic pain induction.
    Authors: Chen Et al.
    Nat Commun  2014;5:5331
  24. IKK regulates the deubiquitinase CYLD at the postsynaptic density.
    Authors: Thein Et al.
    Biochem Biophys Res Commun  2014;450:550
  25. STAT1 negatively regulates spatial memory formation and mediates the memory-impairing effect of Aβ.
    Authors: Hsu Et al.
    Neuropsychopharmacology  2014;39:746
  26. Long-term depression-inducing stimuli promote cleavage of the synaptic adhesion molecule NGL-3 through NMDA receptors, matrix metalloproteinases and presenilin/γ-secretase.
    Authors: Lee Et al.
    Philos Trans R Soc Lond B Biol Sci  2014;369:20130158
  27. Rapid and reversible knockdown of endogenous proteins by peptide-directed lysosomal degradation.
    Authors: Fan Et al.
    Nat Neurosci  2014;17:471
  28. The calcium-sensitive σ-1 receptor prevents cannabinoids from provoking glutamate NMDA receptor hypofunction: implications in antinociception and psychotic diseases.
    Authors: Sánchez-Blázquez Et al.
    Int J Neuropsychopharmacol  2014;17:1943
  29. PICK1 links Argonaute 2 to endosomes in neuronal dendrites and regulates miRNA activity.
    Authors: Antoniou Et al.
    EMBO Rep  2014;15:548
  30. Camkii-mediated phosphorylation regulates distributions of Syngap-α1 and -α2 at the postsynaptic density.
    Authors: Yang Et al.
    PLoS One  2013;8:e71795
  31. Evidence for glutamate as a neuroglial transmitter within sensory ganglia.
    Authors: Kung Et al.
    PLoS One  2013;8:e68312
  32. Membrane potential measurements of isolated neurons using a voltage-sensitive dye.
    Authors: Fairless Et al.
    PLoS One  2013;8:e58260
  33. Activation of group I metabotropic glutamate receptors potentiates heteromeric kainate receptors.
    Authors: Rojas Et al.
    Mol Pharmacol  2013;83:106
  34. HINT1 protein cooperates with cannabinoid 1 receptor to negatively regulate glutamate NMDA receptor activity.
    Authors: Vicente-Sánchez Et al.
    Mol Brain  2013;6:42
  35. Central activation of the A1 adenosine receptor (A1AR) induces a hypothermic, torpor-like state in the rat.
    Authors: Tupone Et al.
    J Neurosci  2013;33:14512
  36. An essential role for inhibitor-2 regulation of protein phosphatase-1 in synaptic scaling.
    Authors: Siddoway Et al.
    J Neurosci  2013;33:11206
  37. On the selectivity of neuronal NOS inhibitors.
    Authors: Pigott Et al.
    Br J Pharmacol  2013;168:1255
  38. Physiological release of endogenous tau is stimulated by neuronal activity.
    Authors: Pooler Et al.
    EMBO Rep  2013;14:389
  39. S-nitrosylation of AMPA receptor GluA1 regulates phosphorylation, single-channel conductance, and endocytosis.
    Authors: Selvakumar Et al.
    Proc Natl Acad Sci U S A  2013;110:1077
  40. Gephyrin-independent GABA(A)R mobility and clustering during plasticity.
    Authors: Niwa Et al.
    PLoS One  2012;7:e36148
  41. Glutamate may be an efferent transmitter that elicits inhibition in mouse taste buds.
    Authors: Huang Et al.
    PLoS One  2012;7:e30662
  42. Molecular pharmacology of human NMDA receptors.
    Authors: Hedegaard Et al.
    Neurochem Int  2012;61:601
  43. Metabotropic glutamate receptor 5 mediates phosphorylation of vascular endothelial cadherin and nuclear localization of β-catenin in response to homocysteine.
    Authors: Beard Et al.
    Vascul Pharmacol  2012;56:159
  44. Glissandi: transient fast electrocorticographic oscillations of steadily increasing frequency, explained by temporally increasing gap junction conductance.
    Authors: Cunningham Et al.
    Epilepsia  2012;53:1205
  45. In vivo comparison of harmine efficacy against psychostimulants: preferential inhibition of the cocaine response through a glutamatergic mechanism.
    Authors: Owaisat Et al.
    Neurosci Lett  2012;525:12
  46. Bidirectional control of mRNA translation and synaptic plasticity by the cytoplasmic polyadenylation complex.
    Authors: Udagawa Et al.
    Mol Cell  2012;47:253
  47. Glutamate carboxypeptidase II (GCPII) inhibitor displays anti-glutamate and anti-cocaine effects in an invertebrate assay.
    Authors: Tallarida Et al.
    Amino Acids  2012;42:2521
  48. The mu-opioid receptor and the NMDA receptor associate in PAG neurons: implications in pain control.
    Authors: Rodríguez-Muñoz Et al.
    Neuropsychopharmacology  2012;37:338
  49. Reducing amyloid-related Alzheimer's disease pathogenesis by a small molecule targeting filamin A.
    Authors: Wang Et al.
    J Neurosci  2012;32:9773
  50. Glutamate controls tPA recycling by astrocytes, which in turn influences glutamatergic signals.
    Authors: Cassé Et al.
    J Neurosci  2012;32:5186
  51. Genetic deletion of TNF receptor suppresses excitatory synaptic transmission via reducing AMPA receptor synaptic localization in cortical neurons.
    Authors: He Et al.
    FASEB J  2012;26:334
  52. Neuroprotective effects of phenolic antioxidant tBHQ associate with inhibition of FoxO3a nuclear translocation and activity.
    Authors: Bahia Et al.
    J Neurochem  2012;123:182
  53. Soybean-derived Bowman-Birk inhibitor inhibits neurotoxicity of LPS-activated macrophages.
    Authors: Li Et al.
    J Neuroinflammation  2011;8:15
  54. Microglial morphology and dynamic behavior is regulated by ionotropic glutamatergic and GABAergic neurotransmission.
    Authors: Fontainhas Et al.
    PLoS One  2011;6:e15973
  55. Functional role of neurotrophin-3 in synapse regeneration by spiral ganglion neurons on inner hair cells after excitotoxic trauma in vitro.
    Authors: Wang and Green
    J Neurosci  2011;31:7938
  56. Activity-dependent ubiquitination of the AMPA receptor subunit GluA2.
    Authors: Lussier Et al.
    J Neurosci  2011;31:3077
  57. SynGAP moves out of the core of the postsynaptic density upon depolarization.
    Authors: Yang Et al.
    Neuroscience  2011;192:132
  58. Exposure of neurons to excitotoxic levels of glutamate induces cleavage of the RNA editing enzyme, adenosine deaminase acting on RNA 2, and loss of GLUR2 editing.
    Authors: Mahajan Et al.
    Neuroscience  2011;189:305
  59. VEGF modulates NMDA receptors activity in cerebellar granule cells through Src-family kinases before synapse formation.
    Authors: Meissirel Et al.
    Proc Natl Acad Sci U S A  2011;108:13782
  60. CB1 modulation of temporally distinct synaptic facilitation among local circuit interneurons mediated by N-type calcium channels in CA1.
    Authors: Ali
    J Neurophysiol  2011;105:1051
  61. Neuroprotective effect of inhaled nitric oxide on excitotoxic-induced brain damage in neonatal rat.
    Authors: Pansiot Et al.
    PLoS One  2010;5:e10916
  62. Calcium binding to PICK1 is essential for the intracellular retention of AMPA receptors underlying long-term depression.
    Authors: Citri Et al.
    J Neurosci  2010;30:16437
  63. Sustained glutamate receptor activation down-regulates GABAB receptors by shifting the balance from recycling to lysosomal degradation.
    Authors: Maier Et al.
    J Biol Chem  2010;285:35606
  64. NR2D-containing NMDA receptors mediate tissue plasminogen activator-promoted neuronal excitotoxicity.
    Authors: Baron Et al.
    Cell Death Differ  2010;17:860
  65. Oligodendrocytes are damaged by neuromyelitis optica immunoglobulin G via astrocyte injury.
    Authors: Marignier Et al.
    Brain  2010;133:2578
  66. Disassembly of shank and homer synaptic clusters is driven by soluble beta-amyloid(1-40) through divergent NMDAR-dependent signalling pathways.
    Authors: Roselli Et al.
    PLoS One  2009;4:e6011
  67. N-MthD.-aspartate receptor- and metabotropic glutamate receptor-dependent long-term depression are differentially regulated by the ubiquitin-proteasome system.
    Authors: Citri Et al.
    Eur J Neurosci  2009;30:1443
  68. Cortical adenylyl cyclase 1 is required for thalamocortical synapse maturation and aspects of layer IV barrel development.
    Authors: Iwasato Et al.
    J Neurosci  2008;28:5931
  69. A quantitative assessment of glutamate uptake into hippocampal synaptic terminals and astrocytes: new insights into a neuronal role for excitatory amino acid transporter 2 (EAAT2).
    Authors: Furness Et al.
    Neuroscience  2008;157:80
  70. An activity-regulated microRNA controls dendritic plasticity by down-regulating p250GAP.
    Authors: Wayman Et al.
    Proc Natl Acad Sci U S A  2008;105:9093
  71. AMPAR exocytosis through NO modulation of PICK1.
    Authors: Sossa Et al.
    Neuropharmacology  2007;53:92
  72. Differential redistribution of native AMPA receptor complexes following LTD induction in acute hippocampal slices.
    Authors: Holman Et al.
    Neuropharmacology  2007;52:92
  73. Synaptic scaffolding molecule alpha is a scaffold to mediate N-MthD.-aspartate receptor-dependent RhoA activation in dendrites.
    Authors: Iida Et al.
    Mol Cell Biol  2007;27:4388
  74. NMDA receptor activation potentiates inhibitory transmission through GABA receptor-associated protein-dependent exocytosis of GABA(A) receptors.
    Authors: Marsden Et al.
    J Neurosci  2007;27:14326
  75. Characterization of the role of microtubule-associated protein 1B in metabotropic glutamate receptor-mediated endocytosis of AMPA receptors in hippocampus.
    Authors: Davidkova and Carroll
    J Neurosci  2007;27:13273
  76. Vesicular release of glutamate from unmyelinated axons in white matter.
    Authors: Ziskin Et al.
    Nat Neurosci  2007;10:321
  77. Activation of group III metabotropic glutamate receptors attenuates rotenone toxicity on DArgic neurons through a microtubule-dependent mechanism.
    Authors: Jiang Et al.
    J Neurosci  2006;26:4318
  78. cAMP-dependent protein kinase postsynaptic localization regulated by NMDA receptor activation through translocation of an A-kinase anchoring protein scaffold protein.
    Authors: Smith Et al.
    J Neurosci  2006;26:2391
  79. Analgesia mediated by the TRPM8 cold receptor in chronic neuropathic pain.
    Authors: Proudfoot Et al.
    Curr Biol  2006;16:1591
  80. Glutamatergic regulation of the p70S6 kinase in primary mouse neurons.
    Authors: Lenz and Avruch
    J Biol Chem  2005;280:38121
  81. Akt-dependent expression of NAIP-1 protects neurons against amyloid-{beta} toxicity.
    Authors: Lesne Et al.
    J Biol Chem  2005;280:24941
  82. Behavioral stress enhances hippocampal CA1 long-term depression through the blockade of the glutamate uptake.
    Authors: Yang Et al.
    J Neurosci  2005;25:4288
  83. Diminished neuronal activity increases neuron-neuron connectivity underlying silent synapse formation and the rapid conversion of silent to functional synapses.
    Authors: Nakayama Et al.
    J Neurosci  2005;25:4040
  84. Neuroprotective activity of the mGluR5 antagonists MPEP and MTEP against acute excitotoxicity differs and does not reflect actions at mGluR5 receptors.
    Authors: Lea Et al.
    Br J Pharmacol  2005;145:527
  85. beta-OE, dehydroepiandrosterone, and dehydroepiandrosterone sulfate protect against N-MthD.-aspartate-induced neurotoxicity in rat hippocampal neurons by different mechanisms.
    Authors: Kurata Et al.
    J Pharmacol Exp Ther  2004;311:237
  86. Cell type-specific interleukin-1beta signaling in the CNS.
    Authors: Srinivasan Et al.
    J Neurosci  2004;24:6482
  87. Subpallial origin of a population of projecting pioneer neurons during corticogenesis.
    Authors: Morante-Oria Et al.
    Proc Natl Acad Sci U S A  2003;100:12468
  88. Presynaptic N-MthD.-aspartate receptors at the parallel fiber-Purkinje cell synapse.
    Authors: Casado Et al.
    Proc Natl Acad Sci U S A  2000;97:11593
  89. Investigations into the mechanism of action of the new anticonvulsant retigabine. Interaction with GABAergic and glutamatergic neurotransmission and with voltage gated ion channels.
    Authors: Rundfeldt
    Arzneimittelforschung  2000;50:1063
  90. Selective mGluR5 antagonists MPEP and SIB-1893 decrease NMDA or glutamate-mediated neuronal toxicity through actions that reflect NMDA receptor antagonism.
    Authors: O'Leary Et al.
    Br J Pharmacol  2000;131:1429
  91. In vivo microdialysis study of a specific inhibitor of soluble guanylyl cyclase on the glutamate receptor/nitric oxide/cyclic GMP pathway.
    Authors: Fedele Et al.
    Br J Pharmacol  1996;119:590

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Induction of chemLTD
By Anonymous on 11/02/2017

Application of NMDA was used to induce synaptic depression in acute brain slice.

Used at 20uM for 3 minutes to induce chemLTD.

Induction of chemLTD 0114
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