NQ 301
Discontinued Product
Chemical Name: 2-[(4-Acetylphenyl)amino]-3-chloro-1,4-naphthalenedione
Purity: ≥98%
Biological Activity
NQ 301 is a selective CD45 inhibitor (IC50 = 200 nM). Exhibits >200-fold selectivity for CD45 over six related protein tyrosine phosphatases. Increases phosphorylation of Lck in Jurkat cells and reduces T cell receptor signaling in acitvated splenocytes in vitro. Blocks inflammation in a delayed-type hypersensitivity model in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Allosteric noncompetitive small molecule selective inhibitors of CD45 tyrosine phosphatase suppress T-cell receptor signals and inflammation in vivo.
Perron et al.
Mol.Pharmacol., 2014;85:553
Product Datasheets
Reconstitution Calculator
Molarity Calculator
FAQs
No product specific FAQs exist for this product, however you may
View all Small Molecule FAQsReviews for NQ 301
There are currently no reviews for this product. Be the first to review NQ 301 and earn rewards!
Have you used NQ 301?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
