NSC 636819
Chemical Name: 1,5-Bis[(1E)-2-(3,4-dichlorophenyl)ethenyl]-2,4-dinitrobenzene
Purity: ≥98%
Biological Activity
NSC 636819 is a KDM4A/KDM4B inhibitor; inhibits histone demethylase activity on H3K9me3 and induces apoptosis in LNCaP prostate cancer cells in vitro. Also negatively regulates androgen-responsive genes.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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KDM4B as a target for prostate cancer: structural analysis and selective inhibition by a novel inhibitor.
Chu et al.
J.Med.Chem., 2014;57:5975
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Used for inhibiting H3K9me3 demethylases on Pancreatic Cancer cell lines. works pretty well.