NSC 687852
Discontinued Product
Chemical Name: 3,5-Bis[(4-nitrophenyl)methylene]-1-(1-oxo-2-propene-1-yl)-4-piperidone
Purity: ≥97%
Biological Activity
NSC 687852 is an inhibitor of 19S regulatory particle associated deubiquitinating enzymes (DUBs), UCHL5 and USP14. Shows minimal inhibition of UCHL-1, UCHL-3, USP2, USP7, USP, BAP1 and proteasome activity. Induces apoptosis by cathepsin D-dependent caspase-cleavage (IC50 = 0.5 μM). Displays antitumor activity in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Induction of the lysosomal apoptosis pathway by inhibitors of the ubiquitin-proteasome system.
Berndtsson et al.
Int.J.Cancer, 2009;124:1463 -
Inhibition of proteasome deubiquitinating activity as a new cancer therapy.
D'Arcy et al.
Nat.Med., 2011;17:1636
Product Datasheets
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