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NVP 2

Catalog #: 6535
5 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6535/5
NVP 2 | CAS No. 1263373-43-8 | Cyclin-dependent Kinase Inhibitors
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Description: Potent and selective ATP-competitive CDK9 inhibitor

Chemical Name: 4-[[[5'-Chloro-2'-[[trans-4-[[(1R)-2-methoxy-1-methylethyl]amino]cyclohexyl]amino][2,4'-bipyridin]-6-yl]amino]methyl]tetrahydro-2H-pyran-4-carbonitrile

Purity: ≥97%

Product Details
Citations (5)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

NVP 2 is a potent and selective ATP-competitive CDK9 inhibitor (IC50 = 0.5 nM). Exhibits selectivity for CDK9 over a panel of 468 kinases, but inhibits DYRK1B (IC50 = 350 nM), displays <90% binding to CDK7 (IC50 >10 μM) and CDK13. Inhibits proliferation of MOLT4 cells in vitro. Induces apoptosis.

Technical Data

M.Wt:
513.07
Formula:
C27H37ClN6O2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥97%
Storage:
Store at -20°C
CAS No:
1263373-43-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citations for NVP 2

The citations listed below are publications that use Tocris products. Selected citations for NVP 2 include:

5 Citations: Showing 1 - 5

  1. Nuclear RNA binding regulates TDP-43 nuclear localization and passive nuclear export.
    Authors: Jeffrey D Et al.
    Cell Rep  2022;40:111106
  2. YAP1 maintains active chromatin state in head and neck squamous cell carcinomas that promotes tumorigenesis through cooperation with BRD4.
    Authors: Brian Et al.
    Cell Rep  2022;39:110970
  3. Ubiquitylation of MYC couples transcription elongation with double-strand break repair at active promoters.
    Authors: Johannes Et al.
    Mol Cell  2021;81:830-844.e13
  4. Localized Inhibition of Protein Phosphatase 1 by NUAK1 Promotes Spliceosome Activity and Reveals a MYC-Sensitive Feedback Control of Transcription.
    Authors: Bernhard Et al.
    Mol Cell  2020;77:1322-1339.e11
  5. CDK8 Fine-Tunes IL-6 Transcriptional Activities by Limiting STAT3 Resident Time at the Gene Loci.
    Authors: Ignacio Et al.
    Cell Rep  2020;33:108545

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