PA 8
Chemical Name: 2-Amino-5,8-dihydro-5-[3-methoxy-4-(2-propen-1-yloxy)phenyl]pyrido[2,3-d]pyrimidine-4,7(3H,6H)-dione
Purity: ≥98%
Biological Activity
PA 8 is a PAC1 receptor antagonist. Inhibits PACAP-induced CREB phosphorylation in PAC1, but not VPAC1 or VPAC2, expressing cells. Also inhibits PACAP-induced increases in cAMP levels in vitro (IC50 = 2 nM) and PACAP-induced aversive responses and mechanical allodynia following intrathecal injection in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
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Background References
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In silico screening identified novel small-molecule antagonists of PAC1 receptor.
Takasaki et al.
J.Pharmacol.Exp.Ther., 2018;365:1
Product Datasheets
Citation for PA 8
The citations listed below are publications that use Tocris products. Selected citations for PA 8 include:
1 Citation: Showing 1 - 1
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PACAP regulation of central amygdala GABAergic synapses is altered by restraint stress.
Authors: Varodayan Et al.
Neuropharmacology 2020;168
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