PAF (C16)
Chemical Name: (7R)-7-(Acetyloxy)-4-hydroxy-N,N,N-trimethyl-3,5,9-trioxa-4-phosphapentacosan-1-aminium-4-oxide
Biological Activity
PAF (C16) is an endogenous platelet-activating factor (PAF) and ligand for PAF receptors. Produced by inflammatory cells and a potent chemoattractant for polymorphonuclear neutrophils. Induces increased vascular permeability.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Impaired P2X1 Receptor-Mediated Adhesion in Eosinophils from Asthmatic Patients
J Immunol, 2016;0(0):. -
Cell chirality regulates intercellular junctions and endothelial permeability
J Fan, P Ray, Y Lu, G Kaur, JJ Schwarz, LQ Wan
Sci Adv, 2018;4(10):eaat2111. -
Molecular species of platelet-activating factor generated by human neutrophils challenged with ionophore A23187.
Oda et al.
J.Immunol., 1985;134:1090 -
Actions of platelet activating factor (PAF) homologues and their combinations on neutrophil chemokinesis and cutaneous inflammatory responses in man.
Archer et al.
J.Invest.Dermatol., 1988;91:82 -
Vasorelaxant effect of C16-PAF and C18-PAF on renal blood flow and systemic blood pressure in the anesthetized rat.
Handa et al.
Life Sci., 1991;49:747
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