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PB 28 dihydrochloride

Catalog #: 2562
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PB 28 dihydrochloride | CAS No. 172907-03-8 | Sigma2 Receptor Agonists
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Description: High affinity σ2 agonist

Chemical Name: 1-Cyclohexyl-4-[3-(1,2,3,4-tetrahydro-5-methoxy-1-naphthalenyl)propyl]piperazine dihydrochloride

Purity: ≥99%

Product Details
Citations (1)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

PB 28 dihydrochloride is a high affinity σ2 receptor agonist (Ki values are 0.8 and 15.2 nM for σ2 and σ1 receptors respectively) that displays minimal affinity at other receptors. Inhibits electrically evoked twitch in guinea pig bladder and ileum (EC50 values are 2.62 and 3.96 μM respectively). Displays antiproliferative and cytotoxic effects in SK-N-SH neuroblastoma and C6 glioma cells.

Technical Data

M.Wt:
443.5
Formula:
C24H38N2O.2HCl
Solubility:
Soluble to 20 mM in water with gentle warming
Purity:
≥99%
Storage:
Desiccate at +4°C
CAS No:
172907-03-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. New σ and 5-HT1A receptor ligands: ω-(tetralin-1-yl)-n-alkylamine derivatives.
    Berardi et al.
    J.Med.Chem., 1996;39:176
  2. A new method for evaluating σ2 ligand activity in the isolated guinea-pig bladder.
    Colabufo et al.
    Naunyn-Schmied.Arch.Pharmacol., 2003;368:106
  3. Antiproliferative and cytotoxic effects of some σ2 agonists and σ1 antagonists in tumour cell lines.
    Colabufo et al.
    Naunyn-Schmied.Arch.Pharmacol., 2004;370:106
  4. NO1, a New Sigma 2 Receptor/TMEM97 Fluorescent Ligand, Downregulates SOCE and Promotes Apoptosis in the Triple Negative Breast Cancer Cell Lines
    C Cantonero, PJ Camello, C Abate, F Berardi, GM Salido, JA Rosado, PC Redondo
    Cancers (Basel), 2020;12(2):.

Product Datasheets

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Citation for PB 28 dihydrochloride

The citations listed below are publications that use Tocris products. Selected citations for PB 28 dihydrochloride include:

1 Citation: Showing 1 - 1

  1. σ1 receptor ligands control a switch between passive and active threat responses.
    Authors: Rennekamp Et al.
    Nat Chem Biol  2016;12:552

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