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PD 146176

Catalog #: 2850
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PD 146176 | CAS No. 4079-26-9 | Lipoxygenase Inhibitors
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Description: Selective 15-lipoxygenase inhibitor

Chemical Name: 6,11-Dihydro[1]benzothiopyrano[4,3-b]indole

Purity: ≥98%

Product Details
Citations (1)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

PD 146176 is a specific, non-competitve 15-lipoxygenase (15-LOX) inhibitor (Ki = 197nM) that has no demonstrable effect on 5-LOX, 12-LOX, COX-1 or COX-2 (IC50 = 0.54 μM for 15-LOX in rabbit reticulocytes). Lacks non-specific antioxidant properties and prevents atherogenesis via regulation of monocyte-macrophage enrichment in vivo.

Technical Data

M.Wt:
237.32
Formula:
C15H11NS
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
4079-26-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Attenuation of diet-induced atherosclerosis in rabbits with a highly selective 15-lipoxygenase inhibitor lacking significant antioxidant properties.
    Sendobry et al.
    Br.J.Pharmacol., 1997;120:1199
  2. A specific 15-lipoxygenase inhibitor limits the progression and monocyte-macrophage enrichment of hypercholesterolemia-induced atherosclerosis in the rabbit.
    Bocan et al.
    Atherosclerosis, 1998;136:203
  3. Anti-Inflammatory Effects of OxPAPC Involve Endothelial Cell-Mediated Generation of LXA4.
    Yunbo Ke, Noureddine Zebda, Olga Oskolkova, Taras Afonyushk, Evgeny Berdyshev, Yufeng Tian, Fanyong Meng, Nicolene Sarich, Valery N Bochkov, Ji Ming Wang, Anna A Birukova, Konstantin G Birukov
    Circulation Research, 2017;0(0):1524-4571.
  4. Enhanced 15-HPETE production during oxidant stress induces apoptosis of endothelial cells.
    Sordillo LM, Weaver JA, Cao YZ, Corl C, Sylte MJ, Mullarky IK
    Prostaglandins Other Lipid Mediat., 2005-05-01;76(1):19-34.

Product Datasheets

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Citation for PD 146176

The citations listed below are publications that use Tocris products. Selected citations for PD 146176 include:

1 Citation: Showing 1 - 1

  1. Plasticity of cytochrome P450 isozyme expression in rat trigeminal ganglia neurons during inflammation.
    Authors: Ruparel Et al.
    Cancer Res  2012;153:2031

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