PETCM
Description: Activator of caspase-3
Chemical Name: α-(Trichloromethyl)-4-pyridineethanol
Purity: ≥99%
Biological Activity
PETCM is a caspase-3 activator. Acts via inhibition of the oncoprotein ProT, therefore stimulates apoptosome formation and subsequent caspase-3 activation in a cytochrome c-dependent manner.Technical Data
M.Wt:
240.52
Formula:
C8H8Cl3NO
Solubility:
Soluble to 50 mM in 1eq. HCl
Purity:
≥99%
Storage:
Store at RT
CAS No:
10129-56-3
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Distinctive roles of PHAP proteins and prothymosin-α in a death regulatory pathway.
Jiang et al.
Science, 2003;299:223 -
Direct activation of the apoptosis machinery as a mechanism to target cancer cells.
Nguyen and Wells
Proc.Natl.Acad.Sci.U.S.A., 2003;100:7533
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