Home / Diacylglycerol O-Acyltransferase (DGAT) Inhibitors / PF 04620110

PF 04620110

Catalog #: 5863
1 Citation Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5863/25
5863/5
PF 04620110 | CAS No. 1109276-89-2 | Diacylglycerol O-Acyltransferase (DGAT) Inhibitors
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Description: Potent and selective DGAT-1 inhibitor; orally bioavailable

Chemical Name: trans-4-[4-(4-Amino-7,8-dihydro-5-oxopyrimido[5,4-f][1,4]oxazepin-6(5H)-yl)phenyl]cyclohexaneacetic acid

Purity: ≥98%

Product Details
Citations (1)
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

PF 04620110 is a potent and selective DGAT-1 inhibitor (IC50 = 19 nM). Exhibits >1000-fold selectivity for DGAT-1 over DGAT-2, and no significant activity against a range of other enzymes, ion channels and receptors. Reduces plasma triglyceride levels in a rat lipid challenge model. Orally bioavailable.

Technical Data

M.Wt:
396.44
Formula:
C21H24N4O4
Solubility:
Soluble to 20 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1109276-89-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.

Background References

  1. Discovery of PF-04620110, a potent, selective, and orally bioavailable inhibitor of DGAT-1.
    Dow et al.
    ACS Med.Chem.Lett., 2011;2:407

Product Datasheets

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Citation for PF 04620110

The citations listed below are publications that use Tocris products. Selected citations for PF 04620110 include:

1 Citation: Showing 1 - 1

  1. ABHD5 suppresses cancer cell anabolism through lipolysis-dependent activation of the AMPK/mTORC1 pathway.
    Authors: Jian Et al.
    J Biol Chem  2020;296:100104

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