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PF 184

Catalog #: 4238
3 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4238/10
PF 184 | CAS No. 1187460-81-6 | IkB Kinase Inhibitors
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Description: Potent and selective IKKβ inhibitor

Chemical Name: 8-[[[5-Chloro-2-[3,4-dimethyl-3,4-bis(hydroxymethyl)-1-pyrrolidinyl]-4-pyridinyl]carbonyl]amino]-1-(4-fluorophenyl)-4,5-dihydro-1H-benz[g]indazole-3-carboxamide

Purity: ≥98%

Product Details
Citations (3)
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

PF 184 is a potent and selective IKKβ inhibitor (IC50 = 37 nM). Displays selectivity over 85 other kinases. Inhibits IL-1β-induced TNF-α production in a steroid-insensitive in vitro model of oxidative stress.

Technical Data

M.Wt:
619.09
Formula:
C32H32ClFN6O4
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1187460-81-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.

Product Datasheets

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Citations for PF 184

The citations listed below are publications that use Tocris products. Selected citations for PF 184 include:

3 Citations: Showing 1 - 3

  1. In vitro benchmarking of NF-κB inhibitors.
    Authors: Charles Et al.
    Eur J Pharmacol  2020;873:172981
  2. Interleukin-1β Induces mtDNA Release to Activate Innate Immune Signaling via cGAS-STING.
    Authors: Michael Et al.
    Mol Cell  2019;74:801-815.e6
  3. Bindarit: an anti-inflammatory small molecule that modulates the NFκB pathway.
    Authors: Mora Et al.
    Cell Cycle  2012;11:159

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