PF 184

Tocris Bioscience | Catalog # 4238

Potent and selective IKKβ inhibitor
Tocris Bioscience

Key Product Details

Description

Potent and selective IKKβ inhibitor
View all IkB Kinase Inhibitors »

Product Description

PF 184 is a potent and selective IKKβ inhibitor (IC50 = 37 nM). Displays selectivity over 85 other kinases. Inhibits IL-1β-induced TNF-α production in a steroid-insensitive in vitro model of oxidative stress.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Product Specifications for PF 184

Molecular Weight

619.09

Formula

C32H32ClFN6O4

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

8-[[[5-Chloro-2-[3,4-dimethyl-3,4-bis(hydroxymethyl)-1-pyrrolidinyl]-4-pyridinyl]carbonyl]amino]-1-(4-fluorophenyl)-4,5-dihydro-1H-benz[g]indazole-3-carboxamide

CAS Number

1187460-81-6

PubChem ID

57519531

InChI Key

JUOWWGNRWRLBSV-MEKGRNQZSA-N

SMILES

FC(C=C4)=CC=C4N(N=C3C(N)=O)C2=C3CCC1=CC=C(NC(C5=CC(N(C6)C[C@@](C)(CO)[C@]6(CO)C)=NC=C5Cl)=O)C=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 61.91 100

Preparing Stock Solutions for PF 184

The following data is based on the product molecular weight 619.09.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.62 mL 8.08 mL 16.15 mL
5 mM 0.32 mL 1.62 mL 3.23 mL
10 mM 0.16 mL 0.81 mL 1.62 mL
50 mM 0.03 mL 0.16 mL 0.32 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 11 publications citing the usage of this product.

Product Documents for PF 184

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for PF 184

For research use only

Customer Reviews for PF 184 (1)

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  • PF 184 blocks LPS-induced TNFa production
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: Macrophages
    Verified Customer | Posted 12/11/2018
    RAW macrophages were incubated with 1 μM PF 184 for 30 min prior to addition of 200 ng/ml LPS for 8 h to follow TNFa mRNA expression. LPS elevated TNFa mRNA levels that was significantly inhibited by pretreatment of cells with PF 184.
    PF 184 4238

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