[(pF)Phe⁴]Nociceptin(1-13)NH₂

Name: [(pF)Phe 4 ]Nociceptin(1-13)NH 2
Brand: Tocris Bioscience
SKU: 1566

Tocris Bioscience | Catalog # 1566

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Product Documents

Potent, selective nociceptin receptor agonist

Discontinued Product

1566 has been discontinued. View all NOP Receptor Agonists products.

Technical Data
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Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices
Research Areas

Key Product Details

Description

Potent, selective nociceptin receptor agonist

View all NOP Receptor Agonists »

Product Description

[(pF)Phe⁴]Nociceptin(1-13)NH₂ is a highly potent and selective nociceptin/orphanin FQ receptor (OP₄) agonist peptide (pK_i = 10.68; pEC₅₀ = 9.80). Displays > 8000-fold selectivity over δ, κ, and μ opioid receptors and has relatively long lasting pronociceptive, hypotensive, negative inotropic and feeding stimulation effects in vivo.

Product Specifications for [(pF)Phe⁴]Nociceptin(1-13)NH₂

Molecular Weight

1399.60

Formula

C₆₁H₉₉FN₂₂O₁₅

Storage

Desiccate at -20°C

CAS Number

380620-88-2

PubChem ID

10260917

InChI Key

OGKNRWXOEHEYOV-QHYQKCGXSA-N

SMILES

[H]N[C@@H](CC1=CC=CC=C1)C(=O)NCC(=O)NCC(=O)N[C@@H](CC1=CC=C(F)C=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 2mg/ml in water

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Background References

References are publications that support the biological activity of the product.

Guerrini Structure-activity studies of the Phe⁴ residue of nociceptin(1-13)-NH₂: Identification of highly potent agonists of the nociceptin/orphanin FQ receptor. J.Med.Chem. 2001 PMID: 11689082
Rizzi Pharmacological characterisation of [(pX)Phe⁴]nociceptin(1-13)amide analogues. 2. In vivo studies. Naunyn Schmiedebergs Arch.Pharmacol. 2002 PMID: 12070758
Bigoni Pharmacological characterisation of [(pX)Phe⁴]nociceptin(1-13)amide analogues. 1. In vitro studies. Naunyn Schmiedebergs Arch.Pharmacol. 2002 PMID: 12070757

Product Documents for [(pF)Phe⁴]Nociceptin(1-13)NH₂

Certificate of Analysis

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Product Specific Notices for [(pF)Phe⁴]Nociceptin(1-13)NH₂

For research use only

Related Research Areas

Neurotransmitter G Protein-Coupled Receptors

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