Philanthotoxin 74
Chemical Name: (S)-N-[7-[(4-Aminobutyl)amino]heptyl]-4-hydroxy-α-[(1-oxobutyl)amino]benzenepropanamide dihydrochloride
Purity: ≥98%
Biological Activity
Philanthotoxin 74 is an AMPA receptor antagonist. Non-selective homomeric GluA3 and GluA1 receptor antagonist (IC50 values are 263 and 296 nM respectively). Inhibits homomeric GluA3 and GluA1 with a 100-fold greater potency than heteromeric GluA1/2 and GluA2/3 receptors.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
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Background References
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Elevated Pressure Increases Ca2+ Influx Through AMPA Receptors in Select Populations of Retinal Ganglion Cells
X Wen, AL Cahill, C Barta, WB Thoreson, S Nawy
Front Cell Neurosci, 2018;12(0):162. -
Evaluation of PhTX-74 as subtype-selective inhibitor of GluA2-containing AMPA receptors.
Poulsen et al.
Mol.Pharmacol., 2013;85:261 -
A subtype-selective, use-dependent inhibitor of native AMPA receptors.
Nilsen and England
J.Am.Chem.Soc., 2007;129:4902
Product Datasheets
Citations for Philanthotoxin 74
The citations listed below are publications that use Tocris products. Selected citations for Philanthotoxin 74 include:
2 Citations: Showing 1 - 2
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Soluble Aβ Oligomers Impair Dipolar Heterodendritic Plasticity by Activation of mGluR in the Hippocampal CA1 Region.
Authors: Zhao Et al.
iScience 2018;6:138
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Calcineurin mediates synaptic scaling via synaptic trafficking of Ca2+-permeable AMPA receptors.
Authors: Kim and Ziff
PLoS Biol 2014;12:e1001900
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